Abstract | BACKGROUND: METHODS: This study was conducted on 50 females in postpartum period. Thyroid hormones, TPO- and Tg-Abs, and percentages of blood lymphocytes were determined. RESULTS: The TPO-Abs were positive in 1(4%),10 (66.7%),6 (60%) of the control, hyperfunction, and hypofunction groups, respectively. The Tg-Abs were positive in 1(4%), 8 (533%), 5 (50%) of same groups, respectively. There was significant negative correlation between serum FT4 and TPO and Tg antibody titers in the hypofunction group. In cases with positive TPO-Abs, there were significantly decreased natural killer cells (NK) and significantly increased activated T cells when compared to the control group and to the TPO negative cases. CONCLUSIONS: The TPO Ab was more sensitive than Tg Ab in predicting PPTD and a high titer of both correlates with the severity of hypothyroidism. Two forms of PPTD appeared to exist: autoimmune form characterized by positive TPO-Ab and increased activated T cells and reduced NK cells and a non immune form without these characteristics.
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Authors | Enas El Sayed Ahmed Swelam, Hoda Gouda Bakr, Marwa Abd El-Azim Mansour |
Journal | Clinical laboratory
(Clin Lab)
Vol. 57
Issue 9-10
Pg. 731-9
( 2011)
ISSN: 1433-6510 [Print] Germany |
PMID | 22029189
(Publication Type: Journal Article)
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Chemical References |
- Autoantibodies
- Thyroglobulin
- Iodide Peroxidase
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Topics |
- Adult
- Autoantibodies
(blood)
- Female
- Humans
- Iodide Peroxidase
(immunology)
- Lymphocytes
(immunology, pathology)
- Postpartum Period
- Predictive Value of Tests
- Pregnancy
- Puerperal Disorders
(immunology, pathology)
- Thyroglobulin
(immunology)
- Thyroid Function Tests
- Thyroiditis, Autoimmune
(immunology, pathology)
- Young Adult
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