Abstract |
The purpose of this work is to study the antimetastasis activity of gadolinium metallofullerenol nanoparticles (f-NPs) in malignant and invasive human breast cancer models. We demonstrated that f-NPs inhibited the production of matrix metalloproteinase ( MMP) enzymes and further interfered with the invasiveness of cancer cells in tissue culture condition. In the tissue invasion animal model, the invasive primary tumor treated with f-NPs showed significantly less metastasis to the ectopic site along with the decreased MMP expression. In the same animal model, we observed the formation of a fibrous cage that may serve as a physical barrier capable of cancer tissue encapsulation that cuts the communication between cancer- and tumor-associated macrophages, which produce MMP enzymes. In another animal model, the blood transfer model, f-NPs potently suppressed the establishment of tumor foci in lung. Based on these data, we conclude that f-NPs have antimetastasis effects and speculate that utilization of f-NPs may provide a new strategy for the treatment of tumor metastasis. FROM THE CLINICAL EDITOR: In this study utilizing metallofullerenol nanoparticles, the authors demonstrate antimetastasis effects and speculate that utilization of these nanoparticles may provide a new strategy in metastatic tumor therapy.
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Authors | Huan Meng, Gengmei Xing, Elvin Blanco, Yan Song, Lina Zhao, Baoyun Sun, Xiaoda Li, Paul C Wang, Alexandru Korotcov, Wei Li, Xing-Jie Liang, Chunying Chen, Hui Yuan, Feng Zhao, Zhen Chen, Tong Sun, Zhifang Chai, Mauro Ferrari, Yuliang Zhao |
Journal | Nanomedicine : nanotechnology, biology, and medicine
(Nanomedicine)
Vol. 8
Issue 2
Pg. 136-46
(Feb 2012)
ISSN: 1549-9642 [Electronic] United States |
PMID | 21930111
(Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, Non-P.H.S.)
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Copyright | Copyright © 2012 Elsevier Inc. All rights reserved. |
Chemical References |
- Matrix Metalloproteinase Inhibitors
- Gadolinium
- Matrix Metalloproteinases
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Topics |
- Animals
- Breast Neoplasms
(drug therapy, enzymology, pathology)
- Cell Line, Tumor
- Female
- Gadolinium
(chemistry, therapeutic use)
- Gene Expression Regulation, Neoplastic
(drug effects)
- Humans
- Lung Neoplasms
(drug therapy, enzymology, secondary)
- Macrophages
(chemistry, drug effects)
- Matrix Metalloproteinase Inhibitors
- Matrix Metalloproteinases
(metabolism)
- Metal Nanoparticles
(chemistry, therapeutic use)
- Mice
- Mice, Inbred BALB C
- Neoplasm Invasiveness
(prevention & control)
- Neoplasm Transplantation
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