Serum adiponectin and bone mineral density in male hemodialysis patients.
Abstract | SUMMARY: Bone mineral density of the 1/3 distal radius, ultra-distal radius, and lumbar spine correlated significantly and negatively with serum adiponectin. There was a significant positive correlation between serum adiponectin and serum NTX. Thus, adiponectin may play a role in mineral and bone disorder in chronic kidney disease stage 5 dialysis (CKD 5D) patients. INTRODUCTION: Serum adiponectin, an adipocyte-produced hormone, has been reported to correlate negatively with bone mineral density (BMD) in the general population. However, little is known about the association between adiponectin and BMD in patients with CKD. METHODS: RESULTS: The BMD of the 1/3 distal radius, ultra-distal radius, and lumbar spine correlated significantly and negatively with serum adiponectin level (r = -0.229, p = 0.014; r = -0.286, p = 0.002; r = -0.227, p = 0.013, respectively). In multiple linear regression analyses, serum adiponectin was significantly and independently associated with the BMD of the 1/3 distal radius (R(2) = 0.173, p < 0.001) and ultra-distal radius (R(2) = 0.278, p < 0.001) after adjustment of age, hemodialysis duration, body weight, %fat mass, and log [intact PTH], although it was not with the BMD of the lumbar spine. There was a significant positive correlation between serum adiponectin and serum NTX (r = 0.321, p < 0.001), although there was no significant correlation between serum adiponectin and serum BAP. CONCLUSION:
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Authors | S Okuno, E Ishimura, K Norimine, N Tsuboniwa, S Kagitani, K Yamakawa, T Yamakawa, K K Sato, T Hayashi, S Shoji, Y Nishizawa, M Inaba |
Journal | Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA
(Osteoporos Int)
Vol. 23
Issue 7
Pg. 2027-35
(Jul 2012)
ISSN: 1433-2965 [Electronic] England |
PMID | 21927917
(Publication Type: Journal Article)
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Chemical References |
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Topics |
- Absorptiometry, Photon
- Adiponectin
(blood)
- Aged
- Biomarkers
(blood)
- Body Composition
(physiology)
- Body Weight
(physiology)
- Bone Density
(physiology)
- Bone Remodeling
(physiology)
- Bone Resorption
(blood, etiology, physiopathology)
- Humans
- Kidney Failure, Chronic
(blood, complications, physiopathology, therapy)
- Lumbar Vertebrae
(physiopathology)
- Male
- Middle Aged
- Radius
(physiopathology)
- Renal Dialysis
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