Baicalin down-regulates the expression of macrophage migration inhibitory factor (MIF) effectively for rats with ulcerative colitis.

Abstract

The purpose of this study was to investigate whether baicalin, a Chinese herbal extract, down-regulates the expression of macrophage migration inhibitory factor (MIF), an inflammatory factor that regulates the function of macrophages (MΦ), in rats with trinitrobenzene sulphonic acid (TNBS)-induced ulcerative colitis (UC). The results showed that baicalin simultaneously down-regulated the expression of MIF, the quantity of MΦs and the amount of MΦ-related cytokines, including macrophage chemotactic factor-1 (MCP-1, CCL2) and macrophage inflammatory protein-3α (MIP-3α, CCL20), in rats with UC. There was no statistical difference between baicailin and mesalazine in down-regulating the expression of MIF. Our study demonstrated that baicalin, an inexpensive but effective monomer, could be a new and alternative pharmaceutical for UC.

• Authors: Shi-Xue Dai, Ying Zou, Yan-Ling Feng, Hong-Bo Liu, Xue-Bao Zheng
• Journal: Phytotherapy research : PTR (Phytother Res) Vol. 26 Issue 4 Pg. 498-504 (Apr 2012) ISSN: 1099-1573 [Electronic] England
• PMID: 21887805 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2011 John Wiley & Sons, Ltd.

Chemical References

• Ccl2 protein, rat
• Ccl20 protein, rat
• Chemokine CCL2
• Chemokine CCL20
• Drugs, Chinese Herbal
• Flavonoids
• Macrophage Migration-Inhibitory Factors
• baicalin
• Mesalamine
• Trinitrobenzenesulfonic Acid
• Intramolecular Oxidoreductases
• Mif protein, rat

Topics

• Animals
• Chemokine CCL2 (metabolism)
• Chemokine CCL20 (metabolism)
• Colitis, Ulcerative (chemically induced, drug therapy, pathology)
• Drug Evaluation, Preclinical
• Drugs, Chinese Herbal (pharmacology)
• Flavonoids (pharmacology)
• Immunohistochemistry
• Intramolecular Oxidoreductases (metabolism)
• Macrophage Migration-Inhibitory Factors (metabolism)
• Macrophages (drug effects)
• Mesalamine (pharmacology)
• Rats
• Rats, Sprague-Dawley
• Trinitrobenzenesulfonic Acid (adverse effects)