Abstract |
Systemic chemotherapy is the only current modality that provides the potential for long-term survival in bladder carcinoma patients with metastatic disease. Overexpression of cyclooxygenase-2 COX-2 induces expression of immune- and cell proliferation-related genes and is associated with the grade, prognosis and recurrence of transitional cell carcinoma of the bladder. There is abundant evidence that aberrant expression of microRNAs ( miRNAs) is implicated in numerous disease states and miRNAs have the potential to be used for cancer therapeutics. Here, we found expression of miR-143 to be low in a series of human bladder carcinomas as compared to background tissue. In addition, restoration of miR-143 by cell transfection in T24 cancer cells led to decreased COX-2 expression, reduced proliferation and mobility. Our findings will help to further understand the functions of miRNAs in cancer cells and point to a specific potential of miR-143 may be employed as a therapeutic agent for bladder carcinoma. The results provide insights into the development of novel tumor markers or new therapeutic strategies.
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Authors | Tao Song, Xu Zhang, Chunyang Wang, Yiguang Wu, Jun Dong, Jiangping Gao, Wei Cai, Baofa Hong |
Journal | Asian Pacific journal of cancer prevention : APJCP
(Asian Pac J Cancer Prev)
Vol. 12
Issue 4
Pg. 929-33
( 2011)
ISSN: 2476-762X [Electronic] Thailand |
PMID | 21790228
(Publication Type: Journal Article)
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Chemical References |
- 3' Untranslated Regions
- Biomarkers, Tumor
- MIRN143 microRNA, human
- MicroRNAs
- Cyclooxygenase 2
- PTGS2 protein, human
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Topics |
- 3' Untranslated Regions
- Biomarkers, Tumor
(genetics, metabolism)
- Carcinoma, Transitional Cell
(genetics, metabolism, pathology)
- Cell Line, Tumor
- Cell Movement
(genetics)
- Cell Proliferation
- Cyclooxygenase 2
(genetics, metabolism)
- Humans
- MicroRNAs
(biosynthesis, genetics)
- Neoplasm Metastasis
- Neoplasm Recurrence, Local
(genetics, pathology)
- Prognosis
- Transfection
(methods)
- Urinary Bladder Neoplasms
(genetics, metabolism, pathology)
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