Abstract | UNLABELLED: OBJECTIVES: This study assessed the effectiveness of an 8-week citicoline treatment period and 4-week follow-up in cocaine-dependent individuals. METHODS: Twenty-nine healthy nontreatment-seeking, cocaine-dependent male and female volunteers were randomized in this double-blind, placebo-controlled study, 18 of whom completed the treatment period of the study. Participants took citicoline (500 mg twice daily) or matched placebo each day and recorded the measures of craving and drug use. Participants visited the laboratory twice a week for urine screens and to attend weekly group therapy sessions. RESULTS: CONCLUSIONS: Although the current preliminary results from this small trial suggest that citicoline is not an effective treatment for heavy cocaine users, further investigation on efficacy citicoline as a treatment for substance dependence in other settings may be warranted.
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Authors | Stephanie C Licata, David M Penetar, Caitlin Ravichandran, John Rodolico, Christopher Palmer, Jeff Berko, Thomas Geaghan, Alison Looby, Erica Peters, Elizabeth Ryan, Perry F Renshaw, Scott E Lukas |
Journal | Journal of addiction medicine
(J Addict Med)
Vol. 5
Issue 1
Pg. 57-64
(Mar 2011)
ISSN: 1932-0620 [Print] Netherlands |
PMID | 21769048
(Publication Type: Journal Article, Randomized Controlled Trial, Research Support, N.I.H., Extramural)
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Chemical References |
- Nootropic Agents
- Cytidine Diphosphate Choline
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Topics |
- Adult
- Cocaine-Related Disorders
(rehabilitation)
- Combined Modality Therapy
- Cytidine Diphosphate Choline
(therapeutic use)
- Double-Blind Method
- Female
- Humans
- Male
- Middle Aged
- Nootropic Agents
(therapeutic use)
- Psychotherapy, Group
- Substance Abuse Detection
- Substance Withdrawal Syndrome
(drug therapy)
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