The effect of a flavonoid fractions diosmin + hesperidin on radiation-induced acute proctitis in a rat model.

Abstract

BACKGROUND:

To explore the protective effect of a flavonoid fractions diosmin + hesperidin (Daflon), against radiation-induced acute proctitis in an experimental rat model.

MATERIALS AND METHODS:

Thirty four rats were divided into four groups. The rats in Group 1 received Daflon and underwent irradiation. The rats in Group 2 received no Daflon and underwent irradiation. The rats in Group 3 received Daflon and underwent sham irradiation. The rats in Group 4 received no Daflon and underwent sham irradiation. Daflon emulsion (100 mg/kg/day) was administered via an orogastric feeding tube to the rats in groups 1 and 3 starting from 1 day prior to irradiation until the euthanasia day (day 15 following irradiation). Radiation therapy was delivered on a cobalt-60 unit using a single fraction of 17.5 Gy defined at a depth of 1 cm through an anterior portal. Slides were examined by the same pathologist under a light microscope two times in a blinded manner.

RESULTS:

When compared to group 2, the rats of Group 1 showed less glandular distortion and less mucosal inflammation with less infiltration of the crypt epithelia by the inflammatory cells (P < 0.001). A statistically significant increase in all parameters but muscular wall thickness was observed for the rats in Group 2 as compared to the group 3 and 4.

CONCLUSIONS:

Administration of a dose of 100 mg/kg/day of the diosmin + hesperidin resulted in decreased morphologic inflammatory changes. This drug may have protective effects against radiation-induced acute proctitis.

• Authors: Atakan Sezer, Ufuk Usta, Zafer Kocak, Mehmet Ali Yagci
• Journal: Journal of cancer research and therapeutics (J Cancer Res Ther) 2011 Apr-Jun Vol. 7 Issue 2 Pg. 152-6 ISSN: 1998-4138 [Electronic] India
• PMID: 21768702 (Publication Type: Journal Article)

Chemical References

• Indoles
• Radiation-Protective Agents
• Sulfonamides
• Diosmin
• hesperadin

Topics

• Acute Disease
• Animals
• Diosmin (pharmacology, therapeutic use)
• Disease Models, Animal
• Female
• Indoles (pharmacology, therapeutic use)
• Intestinal Mucosa (drug effects, pathology, radiation effects)
• Proctitis (prevention & control)
• Radiation Injuries, Experimental (prevention & control)
• Radiation-Protective Agents (pharmacology, therapeutic use)
• Rats
• Rats, Sprague-Dawley
• Rectum (drug effects, pathology, radiation effects)
• Sulfonamides (pharmacology, therapeutic use)