Biochemical and histopathological investigation of the protective effect of disulfiram in ischemia-induced ovary damage.

Abstract

It was biochemically and histopathologically investigated whether disulfiram has protective effects on ischemia-induced ovary damage. For this purpose, levels of tGSH, superoxide dismutase (SOD), malondialdehyde (MDA), and 8-OH Gua/Gua were investigated in ischemic rat ovary tissue. Results show that used doses of disulfiram (10, 25, and 50 mg/kg) prevent MDA, a product of ischemia-induced lipid peroxidation, formation in female rat ovary tissue and prevent decrease of enzymatic and non-enzymatic (SOD, GSH) antioxidant parameters. Additionally, all doses of disulfiram significantly prevent DNA damage when compared to control group. Fewer histopathological findings were observed in tissues with higher antioxidant levels and lower oxidant and DNA damage levels.

• Authors: Unal Isaoglu, Mehmet Yilmaz, Muhammet Calik, Beyzagul Polat, Ebubekir Bakan, Ali Kurt, Yavuz Albayrak, Halis Suleyman
• Journal: Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology (Gynecol Endocrinol) Vol. 28 Issue 2 Pg. 143-7 (Feb 2012) ISSN: 1473-0766 [Electronic] England
• PMID: 21756070 (Publication Type: Journal Article)

Chemical References

• Enzyme Inhibitors
• Protective Agents
• Disulfiram

Topics

• Animals
• DNA Damage
• Disulfiram (therapeutic use)
• Enzyme Inhibitors (therapeutic use)
• Female
• Ischemia (complications)
• Ovarian Diseases (etiology, prevention & control)
• Ovary (blood supply, chemistry, pathology)
• Protective Agents (therapeutic use)
• Rats
• Rats, Wistar