Caspase expression in oral squamous cell carcinoma.

Abstract

BACKGROUND:

Apoptosis is a genetically programmed form of cell death, of which caspases are the central components.

METHODS:

By tissue microarray of 229 cases of oral squamous cell carcinoma (OSCC), we analyzed the immunoexpression of caspases 3, 6, 7, 8, 9, and 10.

RESULTS:

All proteins that we examined were expressed in primary OSCC samples. Caspases 8 and 9 were prominently expressed, and caspases 3, 6, 7, and 10 were occasionally expressed. Disease-free survival differed significantly between caspase 7 high-expressing and low-expressing patients, and our multivariate analysis suggested that expression of caspase 7 is an independent prognostic factor for patients with OSCC.

CONCLUSION:

This study suggests that caspases regulate the tumorigenesis of OSCC and that caspase 7 expression is a predictor of locoregional recurrence of OSCC.

• Authors: Cláudia Malheiros Coutinho-Camillo, Silvia Vanessa Lourenço, Ines Nobuko Nishimoto, Luiz Paulo Kowalski, Fernando Augusto Soares
• Journal: Head & neck (Head Neck) Vol. 33 Issue 8 Pg. 1191-8 (Aug 2011) ISSN: 1097-0347 [Electronic] United States
• PMID: 21755562 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2010 Wiley Periodicals, Inc.

Chemical References

• Biomarkers, Tumor
• Caspases

Topics

• Adult
• Aged
• Biomarkers, Tumor (analysis)
• Biopsy, Needle
• Carcinoma, Squamous Cell (enzymology, genetics, mortality, pathology)
• Case-Control Studies
• Caspases (genetics, metabolism)
• Disease Progression
• Disease-Free Survival
• Female
• Gene Expression Regulation, Neoplastic
• Humans
• Immunohistochemistry
• Kaplan-Meier Estimate
• Male
• Microarray Analysis (methods)
• Middle Aged
• Mouth Neoplasms (enzymology, genetics, mortality, pathology)
• Neoplasm Staging
• Predictive Value of Tests
• Prognosis
• Proportional Hazards Models
• Reference Values
• Survival Analysis
• Tissue Embedding