Abstract | OBJECTIVES: This study was designed to investigate whether a preventive weight management program (WMP) reduces weight gain during olanzapine (OLZ) treatment. Moreover, we examined the effects of intervention on metabolic parameters. METHODS: Patients (N = 100) with schizophrenia or schizoaffective disorder (DSM-IV) who had commenced treatment with OLZ were recruited. Following a run-in period of 4 weeks, 74 patients who had gained at least 1.5 kg body weight were randomized to receive either 12 bi-weekly WMP sessions (prevention group (PG), n = 36), or usual care (control group (CG), n = 38). Anthropometric and metabolic parameters were assessed after the 24-week intervention phase and a 24-week follow-up. RESULTS: Forty-two percent of 74 participants (PG: 36.1%, CG: 47.4%) finished the 24-week intervention phase while 34% of them (PG: 30.6%, CG: 36.8%) completed the 48-week study. There was no significant difference in weight gain between groups (PG: + 3.4 ± 4.2 kg vs. CG: + 4.5 ± 6.1 kg, P = 0.184) after 24 weeks. Nevertheless, PG showed a significantly smaller increase in waist circumference than CG (PG: + 4.6 ± 8.3 cm, CG: + 10.1 ± 7.3 cm, P = 0.019) after 48 weeks. Furthermore, PG showed a significantly smaller increase in fasting glucose (P = 0.031) and 2-h glucose after oral glucose load (P = 0.018) than CG. CONCLUSIONS: These results suggest that preventive WMP may reduce the risk of abdominal obesity and deterioration of glucose metabolism in OLZ-treated patients.
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Authors | Joachim Cordes, Johanna Thünker, Gunnar Regenbrecht, Jürgen Zielasek, Christoph U Correll, Christian Schmidt-Kraepelin, Christian Lange-Asschenfeldt, Marcus W Agelink, Kai G Kahl, Wolfgang Gaebel, Ansgar Klimke, Hans Hauner |
Journal | The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry
(World J Biol Psychiatry)
Vol. 15
Issue 3
Pg. 229-41
(Apr 2014)
ISSN: 1814-1412 [Electronic] England |
PMID | 21745127
(Publication Type: Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
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Chemical References |
- Antipsychotic Agents
- Blood Glucose
- Benzodiazepines
- Olanzapine
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Topics |
- Adult
- Antipsychotic Agents
(adverse effects)
- Benzodiazepines
(adverse effects)
- Blood Glucose
- Body Mass Index
- Diabetes Mellitus, Type 2
(chemically induced, prevention & control)
- Dyslipidemias
(chemically induced, prevention & control)
- Early Medical Intervention
- Female
- Glucose Intolerance
(chemically induced, prevention & control)
- Humans
- Male
- Middle Aged
- Obesity
(chemically induced, prevention & control)
- Olanzapine
- Psychotic Disorders
(drug therapy)
- Schizophrenia
(drug therapy)
- Weight Reduction Programs
(methods)
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