Antimicrobial activity of B-Lock against bacterial and Candida spp. causing catheter-related bloodstream infections.

Abstract

The triple combination trimethoprim, EDTA, and ethanol (B-Lock), is an antimicrobial lock solution for use in indwelling intravascular catheters to prevent and treat catheter-associated infections. B-Lock demonstrated MICs of ≤0.05% (percentage of solution) against Candida spp. (n = 125) and 0.003% to 25% against bacterial strains (n = 175). B-Lock was also fungicidal against the majority of the Candida strains at 6% to 25%. B-Lock demonstrates potential value for the prevention and treatment of catheter-associated infections.

• Authors: M A Ghannoum, N Isham, M R Jacobs
• Journal: Antimicrobial agents and chemotherapy (Antimicrob Agents Chemother) Vol. 55 Issue 9 Pg. 4430-1 (Sep 2011) ISSN: 1098-6596 [Electronic] United States
• PMID: 21730123 (Publication Type: Journal Article, Research Support, N.I.H., Extramural)

Chemical References

• Anti-Infective Agents
• Drug Combinations
• Ethanol
• Edetic Acid
• Trimethoprim

Topics

• Anti-Infective Agents (pharmacology)
• Bacteria (drug effects)
• Candida (drug effects)
• Catheter-Related Infections (microbiology, prevention & control)
• Catheters, Indwelling (microbiology)
• Drug Combinations
• Edetic Acid (pharmacology)
• Ethanol (pharmacology)
• Microbial Sensitivity Tests
• Trimethoprim (pharmacology)