Abstract | CONTEXT: OBJECTIVE: EVIDENCE ACQUISITION: EVIDENCE SYNTHESIS: We conducted a comprehensive analysis of more relevant general population-based and BPH/LUTS or SD clinic-based trials and evaluated the common pathophysiologic mechanisms related to both conditions. In a further step, the overall impact of current BPH/LUTS therapies on sexual life, including phytotherapies, novel drugs, and surgical procedures, was scrutinized. Finally, the usefulness of PDE5-Is in LUTS/BPH was critically analysed, including preclinical and clinical research data as well as possible mechanisms of action that may contribute to the efficacy of PDE5-Is with LUTS/BPH. CONCLUSIONS: Community-based and clinical data demonstrate a strong and consistent association between LUTS and ED, suggesting that elderly men with LUTS should be evaluated for SD and vice versa. Pathophysiologic hypotheses regarding common basics of LUTS and SD as discussed in the literature are (1) alteration of the nitric oxide (NO)-cyclic guanosine monophosphate (cGMP) pathway, (2) enhancement of RhoA- Rho-kinase (ROCK) contractile signalling, (3) autonomic adrenergic hyperactivity, and (4) pelvic atherosclerosis. The most important sexual adverse effects of medical therapies are ejaculation disorders after the use of some α-blockers and sexual desire impairment, ED, and ejaculatory disorders after the use of α- reductase inhibitors. Minimally invasive, conventional, and innovative surgical treatments for BPH may induce both retrograde ejaculation and ED. PDE5-Is have demonstrated significant improvements in both LUTS and ED in men with BPH; combination therapy with PDE5-Is and α1-adrenergic blockers seems superior to PDE5-I monotherapy.
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Authors | Mauro Gacci, Ian Eardley, Francois Giuliano, Dimitris Hatzichristou, Steven A Kaplan, Mario Maggi, Kevin T McVary, Vincenzo Mirone, Hartmut Porst, Claus G Roehrborn |
Journal | European urology
(Eur Urol)
Vol. 60
Issue 4
Pg. 809-25
(Oct 2011)
ISSN: 1873-7560 [Electronic] Switzerland |
PMID | 21726934
(Publication Type: Journal Article, Review)
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Copyright | Copyright © 2011 European Association of Urology. Published by Elsevier B.V. All rights reserved. |
Chemical References |
- Adrenergic alpha-1 Receptor Antagonists
- Phosphodiesterase 5 Inhibitors
- Nitric Oxide
- rho-Associated Kinases
- Cyclic GMP
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Topics |
- Adrenergic alpha-1 Receptor Antagonists
(therapeutic use)
- Atherosclerosis
(drug therapy)
- Clinical Trials as Topic
- Cyclic GMP
(metabolism)
- Drug Therapy, Combination
- Humans
- Lower Urinary Tract Symptoms
(drug therapy, epidemiology, etiology, physiopathology, surgery)
- Male
- Meta-Analysis as Topic
- Nitric Oxide
(metabolism)
- Phosphodiesterase 5 Inhibitors
(therapeutic use)
- Prevalence
- Prostatic Hyperplasia
(complications, drug therapy, epidemiology, physiopathology, surgery)
- Sexual Dysfunction, Physiological
(drug therapy, epidemiology, etiology, physiopathology, surgery)
- rho-Associated Kinases
(metabolism)
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