Abstract | BACKGROUND AND PURPOSE: Delayed paraplegia remains a devastating complication after ischemic spinal cord injury associated with aortic surgery and trauma. Although apoptosis has been implicated in the pathogenesis of delayed neurodegeneration, mechanisms responsible for the delayed paraplegia remain incompletely understood. The aim of this study was to elucidate the role of apoptosis in delayed motor neuron degeneration after spinal cord ischemia. METHODS: RESULTS: CONCLUSIONS:
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Authors | Manabu Kakinohana, Kotaro Kida, Shizuka Minamishima, Dmitriy N Atochin, Paul L Huang, Masao Kaneki, Fumito Ichinose |
Journal | Stroke
(Stroke)
Vol. 42
Issue 8
Pg. 2302-7
(Aug 2011)
ISSN: 1524-4628 [Electronic] United States |
PMID | 21700940
(Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)
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Chemical References |
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Topics |
- Animals
- Apoptosis
(physiology)
- Caspase 3
(genetics, metabolism)
- Cell Survival
- Mice
- Mice, Knockout
- Motor Neurons
(metabolism, pathology)
- Neuroglia
(metabolism, pathology)
- Paraplegia
(etiology, metabolism, pathology)
- Spinal Cord Ischemia
(complications, metabolism, pathology)
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