Abstract | BACKGROUND: METHODS: RESULTS: NAC was performed in 116 of 256 women (45.3%). In NAC group, complete cytoreduction rate and optimal cytoreduction rate were 60.3 and 92.2%, respectively. Although the NAC group comprised patients with higher risk of suboptimal cytoreduction, complete cytoreduction rate was similar to that of PDS group (57.9%, P = .69). Moreover, blood loss and surgical complexity significantly reduced in NAC group (P = .011 and .017). Extensive upper abdominal surgery (EUAS) was performed in 70 of 116 patients (60.3%) in the NAC group. The frequency of EUAS was similar between NAC and PDS group (P = .60). Among NAC group, gross upper abdominal metastasis requiring EUAS was found in 51 patients (44%, 95% confidence interval = 35.3-53.1%). CONCLUSIONS: A significant proportion of patients who received NAC still have gross metastatic tumors requiring EUAS. Gynecologic oncologists should be familiar with EUAS and be ready to perform any required procedures together with multidisciplinary teams, even in the patients who have received NAC.
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Authors | Sokbom Kang, Yoo Heon Jong, Jong Ha Hwang, Myong Cheol Lim, Sang-Soo Seo, Chong-Woo Yoo, Sang-Yoon Park |
Journal | Annals of surgical oncology
(Ann Surg Oncol)
Vol. 18
Issue 13
Pg. 3824-7
(Dec 2011)
ISSN: 1534-4681 [Electronic] United States |
PMID | 21691879
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
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Topics |
- Abdominal Neoplasms
(pathology, surgery)
- Adult
- Aged
- Antineoplastic Combined Chemotherapy Protocols
(therapeutic use)
- Carboplatin
(administration & dosage)
- Chemotherapy, Adjuvant
- Combined Modality Therapy
- Cystadenocarcinoma, Serous
(drug therapy, pathology, surgery)
- Female
- Follow-Up Studies
- Gynecologic Surgical Procedures
- Humans
- Middle Aged
- Neoadjuvant Therapy
- Neoplasm Staging
- Neoplasm, Residual
(drug therapy, pathology, surgery)
- Ovarian Neoplasms
(drug therapy, pathology, surgery)
- Paclitaxel
(administration & dosage)
- Patient Selection
- Prognosis
- Prospective Studies
- Retrospective Studies
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