Abstract | BACKGROUND: Evidence is emerging regarding the relationship between a dysbiosis of the human gut microbiota and a number of gastrointestinal diseases as well as diseases beyond the gut. Probiotics have been investigated in many gastrointestinal disease states, with variable and often modest outcomes. Faecal transplantation is an alternative approach to manipulate the gut microbiota. AIM: METHODS: RESULTS: CONCLUSIONS: Faecal transplantation has been reported with good outcomes for fulminant and refractory C. difficile. No adverse effects of faecal transplantation have been reported. However, there are no level 1 data of faecal transplantation and reports to date may suffer from reporting bias of positive outcomes and under-reporting of adverse effects. This therapy holds great promise, where a dysbiosis of the gut microbiota is responsible for disease and further studies are necessary to explore this potential.
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Authors | J Landy, H O Al-Hassi, S D McLaughlin, A W Walker, P J Ciclitira, R J Nicholls, S K Clark, A L Hart |
Journal | Alimentary pharmacology & therapeutics
(Aliment Pharmacol Ther)
Vol. 34
Issue 4
Pg. 409-15
(Aug 2011)
ISSN: 1365-2036 [Electronic] England |
PMID | 21682755
(Publication Type: Journal Article, Review)
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Copyright | © 2011 Blackwell Publishing Ltd. |
Topics |
- Bacterial Physiological Phenomena
- Feces
(microbiology)
- Gastrointestinal Diseases
(therapy)
- Gastrointestinal Tract
(microbiology)
- Humans
- Microbial Interactions
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