Abstract | PURPOSE: METHODS: Twenty-three eyes of 23 patients received 3 monthly intravitreal ranibizumab injections with or without indocyanine green angiography-guided PDT at baseline. All patients had follow-up of ≥12 months. Visual and anatomical outcomes were compared between the two groups and a PDT monotherapy group. RESULTS: Seven eyes had ranibizumab monotherapy, 16 had combined ranibizumab injections and verteporfin PDT, and 12 had PDT monotherapy. At 3 months, the mean logarithm of minimal angle of resolution best-corrected visual acuity improved from 0.92 to 0.74 in the ranibizumab group (P = 0.18), from 0.70 to 0.59 in the combined group (P = 0.037), and from 0.74 to 0.57 in the PDT monotherapy group (P = 0.014). Complete regression of polypoidal lesions in indocyanine green angiography was found in 1 (14.3%) eye in the ranibizumab group, compared with 15 (93.8%) eyes in the combined group (P = 0.001). Additional PDT and ranibizumab injections in eyes with persistent polyps and fluorescein leakage resulted in regression of polyps in all eyes. At 12 months, no significant difference in logarithm of minimal angle of resolution best-corrected visual acuity and visual change was found between eyes initially treated with ranibizumab monotherapy, combined ranibizumab and PDT, or PDT monotherapy (P = 1.00 and P = 0.11, respectively). CONCLUSION:
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Authors | Timothy Y Y Lai, Gary K Y Lee, Fiona O J Luk, Dennis S C Lam |
Journal | Retina (Philadelphia, Pa.)
(Retina)
Vol. 31
Issue 8
Pg. 1581-8
(Sep 2011)
ISSN: 1539-2864 [Electronic] United States |
PMID | 21610566
(Publication Type: Journal Article)
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Chemical References |
- Antibodies, Monoclonal, Humanized
- Coloring Agents
- Indocyanine Green
- Ranibizumab
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Topics |
- Aged
- Aged, 80 and over
- Antibodies, Monoclonal, Humanized
(therapeutic use)
- Choroid
(blood supply)
- Choroid Diseases
(diagnosis, drug therapy, physiopathology)
- Coloring Agents
- Combined Modality Therapy
- Female
- Fluorescein Angiography
- Follow-Up Studies
- Humans
- Indocyanine Green
- Intravitreal Injections
- Male
- Middle Aged
- Peripheral Vascular Diseases
(diagnosis, drug therapy, physiopathology)
- Photochemotherapy
- Ranibizumab
- Retrospective Studies
- Treatment Outcome
- Visual Acuity
(physiology)
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