Immunohistochemistry of eccrine porocarcinoma.

Abstract

The eccrine porocarcinoma is a rare adnexal tumor of human skin. It has been related to the acrosyringeum of the sweat gland. An immunohistochemical study on paraffin sections of eight porocarcinomas and a control group of 29 poromas was conducted to investigate the differentiation of porocarcinomas. Antibodies against (neuro-) glandular antigens and selected intermediate filaments were used for indirect immunoperoxidase staining with amino ethyl carbazole. Porocarcinomas disclosed variable amounts of cells labeled with CEA, S100A, LS59, NKI/C-3, Cam 5.2, Vim9(1), and wide spectrum keratin. Cellular phenotypes showed greater variability than the benign poromas. The immunostaining patterns of porocarcinomas suggest a differentiation program towards inner duct cells and myoepithelium thereby questioning their classification as acrosyringeal neoplasms.

• Authors: U Wollina, E Castelli
• Journal: Oncology reports (Oncol Rep) Vol. 1 Issue 1 Pg. 101-5 (Jan 1994) ISSN: 1021-335X [Print] Greece
• PMID: 21607315 (Publication Type: Journal Article)