Massive retinal gliosis: an unusual case with immunohistochemical study.

Abstract

Massive retinal gliosis (MRG) is a rare, benign intraocular condition that results from the proliferation of well-differentiated glial cells. Immunohistochemically, these cells show positivity for glial fibrillary acid protein (GFAP), neuron specific enolase (NSE), and S-100 protein. We encountered a case of a 45-year-old female with loss of vision in the left eye. She had a history of trauma to that eye two years ago. Enucleation was carried out, because malignancy was suspected due to retinal calcification. On the basis of light microscopy and immunohistochemistry (IHC) performed on the enucleated eye, it was diagnosed as massive retinal gliosis.

• Authors: Sanjay D Deshmukh, Amrut V Ashturkar, Shridhar V Babanagare, Suvarna K Gokhale, Anand A Deshpande
• Journal: Indian journal of ophthalmology (Indian J Ophthalmol) 2011 May-Jun Vol. 59 Issue 3 Pg. 246-8 ISSN: 1998-3689 [Electronic] India
• PMID: 21586853 (Publication Type: Case Reports, Journal Article)

Chemical References

• Glial Fibrillary Acidic Protein
• S100 Proteins
• Phosphopyruvate Hydratase

Topics

• Blindness (etiology, surgery)
• Eye Enucleation
• Female
• Glial Fibrillary Acidic Protein (metabolism)
• Gliosis (complications, diagnosis, metabolism, physiopathology)
• Humans
• Immunohistochemistry
• Middle Aged
• Phosphopyruvate Hydratase (metabolism)
• Retinal Diseases (complications, diagnosis, metabolism, physiopathology)
• S100 Proteins (metabolism)
• Severity of Illness Index
• Tomography, X-Ray Computed
• Vision, Monocular