[Expression and prognostic value of AKT2 in non-small cell lung cancer].

Abstract

BACKGROUND AND OBJECTIVE:

AKT2 is a critical actor in the PI3K signal transduction pathway. Activation of AKT2 can lead to cell growth and survival. It has been revealed that AKT2 play a central role in tumorigenesis, tumor growth as well as metastasis. The aim of this study is to investigate the association between AKT2 and the clinical outcome of non-small cell lung cancer (NSCLC) patients by detecting its expression levels in the tumor tissue samples.

METHODS:

We developed an immunohistochemistry (IHC) assay to measure AKT2 protein levels in lung specimens from 80 cases with NSCLC and 10 cases with benign pulmonary disease.

RESULTS:

The positive rate of AKT2 was 57.50% (46/80) in NSCLC, which was higher than that in benign pulmonary (10.0%) samples (Chi-square=8.038, P=0.006). There was no significant correlation between AKT2 expression and the clinicopathologic profiles. The expression of AKT2 was significantly correlated with the progression free survival (PFS) (Chi-square=12.671, P=0.005) and the overall survival (OS) (Chi-square=9.851, P=0.021) of patients with NSCLC.

CONCLUSION:

AKT2 may provide a prognostic bio-marker of NSCLC.

• Authors: Xiaohui Miao, Yong Song, Tangfeng Lv, Ping Zhan, Yanling Lv, Dongmei Yuan
• Journal: Zhongguo fei ai za zhi = Chinese journal of lung cancer (Zhongguo Fei Ai Za Zhi) Vol. 14 Issue 5 Pg. 396-9 (May 2011) ISSN: 1999-6187 [Electronic] China
• PMID: 21569643 (Publication Type: English Abstract, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• AKT2 protein, human
• Proto-Oncogene Proteins c-akt

Topics

• Adult
• Aged
• Aged, 80 and over
• Carcinoma, Non-Small-Cell Lung (enzymology, genetics, mortality, pathology)
• Disease-Free Survival
• Female
• Gene Expression Regulation, Neoplastic
• Humans
• Lung Neoplasms (enzymology, genetics, mortality, pathology)
• Male
• Middle Aged
• Prognosis
• Proto-Oncogene Proteins c-akt (genetics, metabolism)