Abstract | CONTEXT:
Anorexia nervosa is complicated by severe bone loss and clinical fractures. Mechanisms underlying bone loss in adults with anorexia nervosa include increased bone resorption and decreased formation. Estrogen administration has not been shown to prevent bone loss in this population, and to date, there are no approved, effective therapies for this comorbidity. OBJECTIVE: DESIGN AND SETTING: We conducted a12-month, randomized, placebo-controlled study at a clinical research center. STUDY PARTICIPANTS: INTERVENTION: MAIN OUTCOME MEASURES: BMD at the spine (primary endpoint), hip, and radius and body composition were measured by dual-energy x-ray absorptiometry. RESULTS:
Risedronate increased posteroanterior spine BMD 3%, lateral spine BMD 4%, and hip BMD 2% in women with anorexia nervosa compared with placebo in a 12-month clinical trial. Testosterone administration did not improve BMD but increased lean body mass. There were few side effects associated with either therapy. CONCLUSIONS:
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Authors | Karen K Miller, Erinne Meenaghan, Elizabeth A Lawson, Madhusmita Misra, Suzanne Gleysteen, David Schoenfeld, David Herzog, Anne Klibanski |
Journal | The Journal of clinical endocrinology and metabolism
(J Clin Endocrinol Metab)
Vol. 96
Issue 7
Pg. 2081-8
(Jul 2011)
ISSN: 1945-7197 [Electronic] United States |
PMID | 21525157
(Publication Type: Journal Article, Randomized Controlled Trial, Research Support, N.I.H., Extramural)
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Chemical References |
- Androgens
- Bone Density Conservation Agents
- Testosterone
- Risedronic Acid
- Etidronic Acid
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Topics |
- Administration, Cutaneous
- Adult
- Androgens
(administration & dosage, therapeutic use)
- Anorexia Nervosa
(complications)
- Bone Density
(drug effects)
- Bone Density Conservation Agents
(pharmacology, therapeutic use)
- Bone Resorption
(drug therapy, etiology)
- Double-Blind Method
- Drug Therapy, Combination
- Etidronic Acid
(analogs & derivatives, pharmacology, therapeutic use)
- Female
- Humans
- Risedronic Acid
- Spine
(drug effects)
- Testosterone
(administration & dosage, therapeutic use)
- Treatment Outcome
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