The medicinal properties of garlic (Allium sativum) have been well known and widely used since historical times. Garlic compounds have received increasing attention during the last few years due to their
cancer chemopreventive properties. The anti-
cancer activity of garlic-derived organosulfur compounds (OSCs) are extensively reported in many
cancers but only a few in the pediatric
tumor neuroblastoma, which warrants exploration of new
therapy for its management. There are some recent reports suggesting that garlic-derived OSCs cause cell cycle arrest, generate
reactive oxygen species (ROS), activate stress
kinases, and also stimulate the mitochondrial pathway for apoptosis in malignant
neuroblastoma. The comprehensive mechanisms of anti-
cancer action of OSCs still remain unclear and require more studies in
neuroblastoma. This review is designed to highlight the molecular mechanisms of anti-
cancer actions of garlic-derived OSCs in
neuroblastoma and as well as in several other
cancers. Further studies should be conducted to establish the clinical expediency of garlic-derived OSCs for treatment of malignant
neuroblastoma in humans.