Abstract | BACKGROUND: METHODS: SHR were fed either normal (SHR-NF, 7% fat) or high fat (SHR-HF, 36% fat) diet and treated with an ARB for 10 weeks. RESULTS: Blood pressure was similar between SHR-NF (190 ± 3 mm Hg) and SHR-HF (192 ± 4 mm Hg) at the end of the 10 week period. Telmisartan and valsartan decreased blood pressure to similar extents in SHR-NF and SHR-HF groups. Body weight was significantly higher in SHR-HF (368 ± 5 g) compared to SHR-NF (328 ± 7 g). Telmisartan but not valsartan significantly reduced the body weight gain in SHR-HF. Telmisartan was also more effective than valsartan in improving glycemic and lipid status in SHR-HF. Monocyte chemoattractant protein-1 (MCP-1), an inflammatory marker, was higher in SHR-HF (24 ± 2 ng/d) compared to SHR-NF (14 ± 5 ng/d). Telmisartan reduced MCP-1 excretion in both SHR-HF and SHR-NF to a greater extent than valsartan. An indicator of renal injury, urinary albumin excretion increased to 85 ± 8 mg/d in SHR-HF compared to 54 ± 9 mg/d in SHR-NF. Telmisartan (23 ± 5 mg/d) was more effective than valsartan (45 ± 3 mg/d) in lowering urinary albumin excretion in SHR-HF. Moreover, telmisartan reduced glomerular damage to a greater extent than valsartan in the SHR-HF. CONCLUSIONS:
|
Authors | Abdul Hye Khan, John D Imig |
Journal | American journal of hypertension
(Am J Hypertens)
Vol. 24
Issue 7
Pg. 816-21
(Jul 2011)
ISSN: 1941-7225 [Electronic] United States |
PMID | 21415842
(Publication Type: Comparative Study, Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)
|
Chemical References |
- Angiotensin II Type 2 Receptor Blockers
- Benzimidazoles
- Benzoates
- Dietary Fats
- PPAR gamma
- Tetrazoles
- Valsartan
- Valine
- Telmisartan
|
Topics |
- Angiotensin II Type 2 Receptor Blockers
(pharmacology, therapeutic use)
- Animals
- Benzimidazoles
(pharmacology, therapeutic use)
- Benzoates
(pharmacology, therapeutic use)
- Blood Pressure
(drug effects, physiology)
- Body Weight
(drug effects, physiology)
- Dietary Fats
(adverse effects)
- Disease Models, Animal
- Hypertension
(drug therapy, physiopathology)
- Kidney Diseases
(physiopathology, prevention & control)
- Male
- Metabolic Syndrome
(chemically induced, physiopathology)
- PPAR gamma
(physiology)
- Rats
- Rats, Inbred SHR
- Telmisartan
- Tetrazoles
(pharmacology, therapeutic use)
- Treatment Outcome
- Valine
(analogs & derivatives, pharmacology, therapeutic use)
- Valsartan
|