[Selective hemoperfusion in gram-negative severe sepsis of patients after cardiac surgery: a prospective randomized study].

Abstract

Early in the new millennium, sepsis remains one of the most urgent problems of modern reanimatology. Endotoxin, a component of the cell wall of gram-negative bacteria is of paramount importance in the pathogenesis of sepsis. Complex intensive care for severe sepsis involves selective endotoxin hemoperfusion with Polymyxin B and Alteco LPS adsorber, which has been performed in 2 patients. This study will enable specialists to formulate their opinion as to whether it is expedient to incorporate selective endotoxin hemoperfusion into complex intensive care for severe sepsis.

• Authors: M B Iarustovskiĭ, M V Abramian, Z V Popok, E I Nazarova, O S Stupchenko, D A Popov, M G Pliushch
• Journal: Anesteziologiia i reanimatologiia (Anesteziol Reanimatol) 2010 Sep-Oct Issue 5 Pg. 60-5 ISSN: 0201-7563 [Print] Russia (Federation)
• PMID: 21395144 (Publication Type: Journal Article, Randomized Controlled Trial)

Chemical References

• Lipopolysaccharides
• Polymyxin B

Topics

• APACHE
• Cardiac Surgical Procedures
• Double-Blind Method
• Gram-Negative Bacterial Infections (blood, microbiology, therapy)
• Hemoperfusion (methods)
• Humans
• Lipopolysaccharides (blood)
• Polymyxin B (administration & dosage, therapeutic use)
• Postoperative Complications (blood, microbiology, therapy)
• Prospective Studies
• Sepsis (blood, microbiology, therapy)
• Treatment Outcome