Polymyxin B (Aerosporin)

A mixture of polymyxins B1 and B2, obtained from Bacillus polymyxa strains. They are basic polypeptides of about eight amino acids and have cationic detergent action on cell membranes. Polymyxin B is used for infections with gram-negative organisms, but may be neurotoxic and nephrotoxic.

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Networked: 786 relevant articles (99 outcomes, 95 trials/studies)

Relationship Network

Drug Context: Research Results

Experts

1.	Nakamura, Tsukasa: 15 articles (12/2011 - 05/2002)
2.	Nation, Roger L: 14 articles (07/2015 - 12/2007)
3.	Li, Jian: 14 articles (07/2015 - 12/2007)
4.	Koide, Hikaru: 14 articles (09/2011 - 05/2002)
5.	Tam, Vincent H: 11 articles (02/2015 - 09/2005)
6.	Kawagoe, Yasuhiro: 11 articles (12/2011 - 01/2004)
7.	Zavascki, Alexandre P: 10 articles (10/2015 - 11/2008)
8.	Ronco, Claudio: 9 articles (09/2015 - 01/2005)
9.	Obata, Toru: 9 articles (12/2013 - 03/2006)
10.	Ueda, Yoshihiko: 9 articles (09/2011 - 01/2004)

Related Diseases

1.	Septic Shock (Toxic Shock Syndrome) 08/01/2007 - "Early initiation of polymyxin B-immobilized fiber therapy effective for septic shock after aortic replacement." 04/01/2010 - "Effectiveness of endotoxin scattering photometry for determining the efficacy of polymyxin B-immobilized fiber treatment in septic shock: report of a case." 11/01/2015 - "Polymyxin B haemoperfusion in septic shock patients." 01/01/2011 - "Cost-effectiveness analysis of polymyxin-B immobilized fiber column and conventional medical therapy in the management of abdominal septic shock in Italy." 01/01/2010 - "Application of polymyxin B convalently immobilized fiber in patients with septic shock."
2.	Infection 09/01/2013 - "In the present scenario of rising infections with MDR gram -ve micro-organisms, this pilot study suggests that polymyxin B can be used effectively and safely in patients not receiving other nephrotoxic drugs, with cautious administration in older patients as they are more vulnerable to nephrotoxicity caused by polymyxin B." 05/01/2013 - "The limited exposure of polymyxin B in ELF observed was consistent with the less favourable efficacy of polymyxin B reported for the treatment of pulmonary infections. " 09/01/2008 - "Our data suggest that polymyxin B may be effective for MDR gram-negative infections in patients with limited therapeutic options, but precautions should be taken to avoid toxicity." 11/01/2002 - "These data suggest that direct delivery of liposomal polymyxin B to the lung can be effective in the treatment of pulmonary infection with P. " 03/01/1991 - "Of the several compounds tested, polymyxin B showed the strongest inhibition in vitro, preventing growth at a concentration of less than or equal to 10 micrograms/ml. Polymyxin B administered in the drinking water was effective in vivo for preventing infections in 1-day-old chickens but did not remove established infections in 1-week-old chickens. "
3.	Sepsis (Septicemia) 08/01/1998 - "Endotoxin removal column containing polymyxin B immobilized fiber is useful for the treatment of the patient with Vibrio vulnificus septicemia." 04/01/2014 - "The purpose of this study was to evaluate the safety and effectiveness of selective lipopolysaccharide (LPS)-adsorption therapy using polymyxin B immobilized fiber cartridges in adult patients complicated with severe sepsis after cardiac surgery. " 05/01/2014 - "To evaluate the safety and effectiveness of selective lipopolysaccharide (LPS)-adsorption therapy using polymyxin B immobilised fibre cartridges in adult patients complicated with severe sepsis after cardiac surgery. " 04/01/2014 - "Endotoxin adsorption using polymyxin B immobilized fiber cartridges in severe sepsis patients following cardiac surgery." 06/01/2013 - "Exposing Escherichia coli-positive blood samples to polymyxin B-functionalized nanomagnets even impairs the ability of gram-negative bacteria to form colony forming units, thus making magnetic separation based blood purification a promising new approach for future sepsis treatment."
4.	Endotoxemia 07/01/1989 - "In this group, polymyxin B also accomplished a reduction in endotoxemia from preoperative to postoperative cases, but there was no significant reduction in clinical complication rate or mortality. " 01/01/1992 - "It is concluded that polymyxin B is a safe and effective treatment against endotoxemia." 09/15/2013 - "Administration of polymyxin B IV in healthy neonatal foals challenged with lipopolysaccharide attenuated some clinical and serum biochemical derangements associated with endotoxemia." 09/15/2013 - "To evaluate the effect of IV administration of polymyxin B on clinical and serum biochemical variables in foals with experimental endotoxemia. " 09/15/2013 - "Effects of intravenous administration of polymyxin B in neonatal foals with experimental endotoxemia."
5.	Wounds and Injuries (Trauma) 10/15/2014 - "The similar has been shown for combination with polymyxin B; furthermore, the myrtle essential oil resulted in re-sensitization of the MDR wound isolates, i.e. " 10/01/2012 - "The cationic antibiotic polymyxin B (PMB) is commonly used as a topical antibiotic for wound care. " 01/01/2000 - "Surveillance cultures of personnel and the environment; molecular genotyping of isolates; cohorting of colonized or infected patients and staff; and topical application of polymyxin B to colonized wounds have been used to enhance standard infection control procedures. " 01/01/1992 - "Effect of polymyxin B on intestinal bacterial translocation in Pseudomonas aeruginosa wound-colonized burned mice." 12/01/1989 - "To Polymyxin-B, strains isolated from wound surfaces were of 86.1% and 90.7% respectively, from subeschar tissues or visceral organs were of 53.8% and 39.3%, from blood stream were of 44.4% and 40%. "

Related Drugs and Biologics

1.	Neomycin
2.	Bacitracin (Baci-Rx)
3.	Trimethoprim (Proloprim)
4.	Gramicidin (Gramicidin A)
5.	Ofloxacin (Levofloxacin)
6.	Ciprofloxacin (Cipro)
7.	Polymyxin B (Aerosporin)
8.	Amphotericin B (Amphotericin)
9.	moxifloxacin (Avelox)
10.	Silver Sulfadiazine (SSD)

Related Therapies and Procedures

1.	Hemoperfusion
2.	Renal Dialysis (Hemodialysis)
3.	Oral Administration
4.	Peritoneal Dialysis
5.	Intramuscular Injections