Hemoperfusion

Removal of toxins or metabolites from the circulation by the passing of blood, within a suitable extracorporeal circuit, over semipermeable microcapsules containing adsorbents (e.g., activated charcoal) or enzymes, other enzyme preparations (e.g., gel-entrapped microsomes, membrane-free enzymes bound to artificial carriers), or other adsorbents (e.g., various resins, albumin-conjugated agarose).

Also Known As:

Networked: 1312 relevant articles (121 outcomes, 113 trials/studies)

Relationship Network

Therapy Context: Research Results

Experts

1.	Nakamura, Tsukasa: 12 articles (12/2011 - 05/2002)
2.	Koide, Hikaru: 11 articles (09/2011 - 05/2002)
3.	Ronco, Claudio: 9 articles (09/2015 - 01/2007)
4.	Miki, Takahiro: 9 articles (01/2014 - 01/2005)
5.	Obata, Toru: 9 articles (12/2013 - 03/2006)
6.	Kawagoe, Yasuhiro: 8 articles (12/2011 - 01/2005)
7.	Sakamoto, Yuichiro: 8 articles (10/2010 - 11/2006)
8.	Mashiko, Kunihiro: 8 articles (10/2010 - 11/2006)
9.	Saito, Takeshi: 8 articles (12/2009 - 01/2005)
10.	Kushi, Hidehiko: 8 articles (12/2009 - 01/2005)

Related Diseases

1.	Poisoning 11/01/2012 - "To evaluate the therapeutic efficacy of hemoperfusion in the treatment of intermediate myasthenia syndrome (IMS) following acute organophosphate poisoning (AOPP). " 11/01/2012 - "[To evaluate the therapeutic efficacy of hemoperfusion in treating intermediate syndrome following acute organophosphate poisoning]." 09/01/2007 - "The present study was conducted to investigate the efficacy of hemoperfusion (HP) on poisoning, and the pharmacokinetics of the poison during and after HP. " 05/01/2012 - "In this case study, the poisoned patient's clinical condition and laboratory values improved gradually after she received hemoperfusion (HP) and plasma exchange, which indicated that the therapy with HP and plasma exchange were helpful in the treatment of 1,2,3-TCP poisoning." 11/01/2005 - "In acute organophosphate poisoning, the efficacy of hemoperfusion on clinical status and mortality."
2.	Septic Shock (Toxic Shock Syndrome) 10/01/2007 - "Direct hemoperfusion with the PMX-05R column is effective in ameliorating clinical and laboratory abnormalities in elderly septic shock patients." 01/01/2006 - "Direct hemoperfusion (DHP) with polymixin B-immobilized fiber (PMX) has been reported to be effective for patients with septic shock. " 02/01/2013 - "We sought to investigate the role of CD4(+)CD25(+)Foxp3(+) Tregs in septic patients, and to evaluate the effect of hemoperfusion with PMX-F on the recovery from immunosuppression owing to septic shock. " 01/01/2010 - "We treated 36 patients with septic shock using direct hemoperfusion with PMX. " 10/01/2007 - "We performed direct hemoperfusion twice with the PMX-05R column in 8 septic shock patients who were over 80 years of age. "
3.	Sepsis (Septicemia) 01/01/2013 - "This study aimed to observe the effect of hemoperfusion (HP) cartridge on different internal environment indicators at different time points in patients with acute blood poisoning and to find alternative indicators for the detection of blood poisoning. " 09/01/2010 - "This study will enable specialists to formulate their opinion as to whether it is expedient to incorporate selective endotoxin hemoperfusion into complex intensive care for severe sepsis." 09/01/2010 - "[Selective hemoperfusion in gram-negative severe sepsis of patients after cardiac surgery: a prospective randomized study]." 09/01/1978 - "[Use of hemosorption in the treatment of sepsis (an experimental study)]." 05/15/2015 - "At the present time, endotoxin removal through cartridge hemoperfusion is one of the better alternatives to combat sepsis. "
4.	Shock 02/01/2009 - "The present study compared the effects of direct hemoperfusion (DHP) using a cytokine absorbing (CTR) column with those using an endotoxin absorbing (PMX) column with endotoxin-induced shock in rats. " 06/01/1980 - "[Studies on direct hemoperfusion by activated charcol in endotoxin shock (author's transl)]." 07/01/2014 - "All the 7 HLAP patients went through fast, gastrointestinal decompression, anti-shock treatment, inhibition of pancreatic secretion, antiseptic treatments, and hemoperfusion (HP) combined with continuous veno venous hemodiafiltration (CVVHDF). " 01/01/2014 - "Immediate initiation of hemoperfusion treatment with polymixin B immobilized fiber (PMX-DHP) is a potent strategy to improve hemodynamics in septic patients with critical circulatory failure. " 06/01/2011 - "We describe the use of synthesized resin-absorbed hemoperfusion in the therapy of a 48-year-old man who developed carotic, cardiovascular shock and multiorgan dysfunction due to a CBZ overdose (the highest concentration of drug >20 mg/L; therapeutic range, 8-12 mg/L). "
5.	Infection 02/15/2002 - "Finally, RT-PCR, SS-PCR, and PERV-specific RT assay detected no PERV infection in the blood samples obtained from five study patients both before and at various times post-hemoperfusion. " 12/01/2014 - "An appreciable part of the structural and functional changes in the liver in patients with HCV and HBV infections was caused by the therapeutic complex, including programmed hemoperfusion." 02/28/2006 - "Finally, RT-PCR detected no PERV infection was found in the blood samples obtained from three patients at various times post-hemoperfusion. " 03/01/1999 - "Medical workers, mental inpatients, hematological patients, patients hospitalized at hemoperfusion departments, and imprisoned subjects were referred to groups at risk of HCV infection: antiHCV were detected in 3.9, 5.4, 13.8, 53.6, and 24.5% of these groups, respectively. " 01/01/1989 - "A favorable effect of hemosorption in infections was based on highly effective correction of microcirculatory disorders as a result of the removal of high molecular substances of microbic and endogenous origin."

Related Drugs and Biologics

1.	Polymyxin B (Aerosporin)
2.	Charcoal (Charbon)
3.	Paraquat
4.	Carbamazepine (Tegretol)
5.	Methotrexate (Mexate)
6.	Polymyxins (Polymyxin)
7.	Valproic Acid (Valproate, Semisodium)
8.	Leucovorin (Folinic Acid)
9.	Carbon
10.	Oxygen

Related Therapies and Procedures

1.	Renal Dialysis (Hemodialysis)
2.	Plasmapheresis
3.	Drug Therapy (Chemotherapy)
4.	Plasma Exchange
5.	Artificial Liver (Bioartificial Liver)