Amphiphilic polymer-coated hybrid nanoparticles as CT/MRI dual contrast agents.

Abstract	We describe hybrid nanoparticles, composed of iron oxide and gold nanoparticles, as potential dual contrast agents for both computed tomography (CT) and magnetic resonance imaging (MRI). The hybrid nanoparticles are synthesized by thermal decomposition of mixtures of Fe-oleate and Au-oleylamine complexes. Using a nano-emulsion method, the nanoparticles are coated with amphiphilic poly(DMA-r-mPEGMA-r-MA) to impart water-dispersity and antibiofouling properties. An in vitro phantom study shows that the hybrid nanoparticles have high CT attenuation, because of the constituent gold nanoparticles, and afford a good MR signal, attributable to the contained iron oxide nanoparticles. Intravenous injection of the hybrid nanoparticles into hepatoma-bearing mice results in high contrast between the hepatoma and normal hepatic parenchyma in both CT and MRI. These results suggest that the hybrid nanoparticles may be useful as CT/MRI dual contrast agents for in vivo hepatoma imaging.
Authors	Dongkyu Kim, Mi Kyung Yu, Tae Sup Lee, Jae Jun Park, Yong Yeon Jeong, Sangyong Jon
Journal	Nanotechnology (Nanotechnology) Vol. 22 Issue 15 Pg. 155101 (Apr 15 2011) ISSN: 1361-6528 [Electronic] England
PMID	21389582 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References	Amines Contrast Media Magnetite Nanoparticles Methacrylates Polymers dodecyl methacrylate polyethylene glycol methacrylate methacrylic acid Polyethylene Glycols Gold oleylamine
Topics	Amines (chemistry) Animals Contrast Media (chemical synthesis, chemistry) Gold (chemistry) Light Liver (pathology) Liver Neoplasms, Experimental (pathology) Magnetic Resonance Imaging Magnetite Nanoparticles (chemistry) Metal Nanoparticles (chemistry) Methacrylates (chemistry) Mice Mice, Inbred Strains Microscopy, Electron, Transmission Particle Size Polyethylene Glycols (chemistry) Polymers (chemical synthesis, chemistry) Scattering, Radiation Solubility Spectrophotometry Tomography, X-Ray Computed

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