[Proportion of intermediate epithelial cells and human prostate cancer].

Abstract

OBJECTIVE:

To study the different proportions of intermediate epithelial cells in human prostate cancer tissue and their clinical significance.

METHODS:

We performed immunohistochemical staining for Cytokeratin 5 (CK5) and Cytokeratin 8 (CK8) on 60 samples of human prostate cancer, determined the proportions of intermediate epithelial cells in the cancer tissue, and classified the samples into 2 types, one with a majority of intermediate epithelial cells (CaP-INT, n = 32), and the other composed mostly of luminal epithelial cells (CaP-LUM, n = 28). Then we compared the 2 types of prostate cancer in the expression of the androgen receptor (AR), age of the patient, serum t-PSA, prostate volume, Gleason score, clinical stage, androgen resistance, and incidence of distant metastasis.

RESULTS:

CaP-INT showed a significantly lower expression of AR ([24.42 +/- 11.41] %) and a higher incidence of distant metastasis (n = 14) than CaP-LUM ([77.21 +/- 10.22] % and n = 4) (P < 0.05). In the CaP-INT group, 6 of the 26 endocrinologically treated cases developed into androgen-independent prostate cancer (AIPC), while in the CaP-LUM group, only 1 out of 23 (P < 0.05). The former also showed remarkably higher clinical stages than the latter (P < 0.05), but no significant differences were found in age, serum t-PSA, prostate volume and Gleason score between the two groups (P > 0.05).

CONCLUSION:

A higher proportion of intermediate epithelial cells may lead to increased invasiveness and metastasis of human prostate cancer.

• Authors: Dian-Jun Yu, Yue-Qing Tang, Yun-Feng Shi, Yong-Chuan Wang, Jian Zhuo, Yi-Yong Zhu, Xiao-Wen Sun, Shu-Jie Xia
• Journal: Zhonghua nan ke xue = National journal of andrology (Zhonghua Nan Ke Xue) Vol. 16 Issue 12 Pg. 1063-7 (Dec 2010) ISSN: 1009-3591 [Print] China
• PMID: 21348194 (Publication Type: Comparative Study, English Abstract, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Receptors, Androgen

Topics

• Aged
• Aged, 80 and over
• Cell Count
• Cell Differentiation
• Epithelial Cells (classification, pathology)
• Humans
• Male
• Middle Aged
• Prostate (pathology)
• Prostatic Neoplasms (pathology)
• Receptors, Androgen (metabolism)