Nesidioblastosis associated with chronic experimental pancreatitis produced by a scorpion toxin, tityustoxin, in rats.

Abstract

Tityustoxin (TsTx), the purified venom of the Brazilian scorpion Tityus serrulatus, was injected intravenously (50 micrograms/kg) into rats, producing a typical picture of chronic pancreatitis after 20 days. Nesidioblastosis, a lesion characterized by hyperplasia of the islets of Langerhans, was also detected in a high percentage (40%) of animals. TsTx-induced pancreatitis may be a useful model for the study of nesidioblastosis in laboratory animals.

• Authors: G Novaes, A Chetto-de-Queiroz, C De-Carvalho-Cardoso, M H Burlacchini-de-Carvalho, L A Ribeiro-Filho, A Oliveira-Gonçalves
• Journal: Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas (Braz J Med Biol Res) Vol. 23 Issue 11 Pg. 1149-51 ( 1990) ISSN: 0100-879X [Print] Brazil
• PMID: 2133023 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Scorpion Venoms
• tityustoxin

Topics

• Animals
• Chronic Disease
• Injections, Intravenous
• Male
• Pancreatic Diseases (pathology)
• Pancreatitis (chemically induced, pathology)
• Rats
• Scorpion Venoms (toxicity)