Abstract | OBJECTIVE:
Acute pancreatitis is an inflammatory condition that may lead to multisystemic organ failure. Melanocortin peptides have been successfully used in experimental models of organ failure and shock, and their protective effect occurs through the activation of a vagus nerve-mediated cholinergic anti-inflammatory pathway by acting at brain melanocortin 4 receptors. In the light of these observations, we studied the effects of the selective melanocortin 4 receptor agonist RO27-3225 in an experimental model of cerulein-induced pancreatitis. DESIGN: Randomized experiment. SETTING: Research laboratory at a university hospital. SUBJECT: INTERVENTIONS: MEASUREMENTS AND MAIN RESULTS: CONCLUSIONS: Our data show that melanocortin 4 receptor agonists reduce pancreatitis severity through the activation of the cholinergic anti-inflammatory pathway. These findings could be of particular interest in the clinical setting.
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Authors | Letteria Minutoli, Francesco Squadrito, Piero Antonio Nicotina, Daniela Giuliani, Alessandra Ottani, Francesca Polito, Alessandra Bitto, Natasha Irrera, Giuseppe Guzzo, Luca Spaccapelo, Carmine Fazzari, Antonio Macrì, Herbert Marini, Salvatore Guarini, Domenica Altavilla |
Journal | Critical care medicine
(Crit Care Med)
Vol. 39
Issue 5
Pg. 1089-96
(May 2011)
ISSN: 1530-0293 [Electronic] United States |
PMID | 21263321
(Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't, Retracted Publication)
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Chemical References |
- Cholinergic Agents
- Inflammation Mediators
- Interleukin-6
- Peptides
- Receptor, Melanocortin, Type 4
- Receptors, Nicotinic
- Tumor Necrosis Factor-alpha
- butir-His-Phe-Arg-Trp-Sar-NH2
- Ceruletide
- Peroxidase
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Topics |
- Acute Disease
- Analysis of Variance
- Animals
- Blotting, Western
- Ceruletide
(pharmacology)
- Cholinergic Agents
(metabolism)
- Disease Models, Animal
- Immunohistochemistry
- Inflammation Mediators
(metabolism)
- Interleukin-6
(metabolism)
- Male
- Pancreatitis
(chemically induced, drug therapy, pathology)
- Peptides
(pharmacology)
- Peroxidase
(metabolism)
- Random Allocation
- Rats
- Rats, Sprague-Dawley
- Receptor, Melanocortin, Type 4
(agonists, therapeutic use)
- Receptors, Nicotinic
(metabolism)
- Sensitivity and Specificity
- Severity of Illness Index
- Signal Transduction
(drug effects)
- Tumor Necrosis Factor-alpha
(metabolism)
- Vagus Nerve
(drug effects)
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