Assessment of cerebral hemodynamics to acetazolamide using brain perfusion SPECT in cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy.

Abstract

Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is a hereditary microangiopathy caused by mutations in the Notch3 gene located on chromosome 19, leading to 4 cardinal features with aura, cerebrovascular ischemic events, mood disturbances, and dementia. Acetazolamide (ACZ) has been promoted as a drug to determine cerebral hemodynamics, including cerebral blood flow (CBF) and cerebrovascular reactivity (CVR) in patients with cerebrovascular disease. In CADASIL patients with small-vessel disease, ACZ may be possible to increase CBF. We present that reduced CBF was dramatically improved after administration of ACZ on Tc-99m ECD brain perfusion SPECT in a CADASIL patient.

• Authors: Soon-Ah Park, Chung-Yong Yang, See-Sung Choi, Woo Hyoung Kim
• Journal: Clinical nuclear medicine (Clin Nucl Med) Vol. 36 Issue 2 Pg. 158-9 (Feb 2011) ISSN: 1536-0229 [Electronic] United States
• PMID: 21220990 (Publication Type: Case Reports, Journal Article)

Chemical References

• Acetazolamide

Topics

• Acetazolamide (pharmacology, therapeutic use)
• Brain (blood supply, diagnostic imaging, drug effects)
• CADASIL (diagnostic imaging, drug therapy, physiopathology)
• Female
• Hemodynamics (drug effects)
• Humans
• Middle Aged
• Perfusion Imaging
• Tomography, Emission-Computed, Single-Photon