Serodiagnosis of gut tuberculosis.

Abstract

The efficacy of enzyme-linked immunosorbent assay (ELISA) in the diagnosis of gut tuberculosis was evaluated. The study included 95 patients with gut tuberculosis, 40 with pulmonary tuberculosis, 25 with non-tubercular intestinal diseases and 40 healthy controls. Mantoux response and antibody titre against PPD using ELISA were studied. The ELISA sensitivity in gut tuberculosis was 80% and in pulmonary tuberculosis 90%. It was also positive in 12% of patients with non-tubercular intestinal diseases and 5% of healthy controls. The sensitivity of Mantoux test in gut (77%) and pulmonary (84%) tuberculosis was comparable to that of ELISA. However, Mantoux test lacked diagnostic significance due to high positivity in non-tubercular disease patients (55%) and healthy controls (56%), whereas ELISA was highly specific (93%) for the diagnosis of gut tuberculosis.

• Authors: V Singh, A K Jain, R K Lal, V K Srivastava, S Khanna, S Gupta, J P Gupta
• Journal: The Journal of the Association of Physicians of India (J Assoc Physicians India) Vol. 38 Issue 4 Pg. 267-9 (Apr 1990) ISSN: 0004-5772 [Print] India
• PMID: 2118133 (Publication Type: Journal Article)

Chemical References

• Antibodies, Bacterial

Topics

• Antibodies, Bacterial (analysis)
• Enzyme-Linked Immunosorbent Assay
• Humans
• Mycobacterium tuberculosis (immunology)
• Tuberculin Test
• Tuberculosis, Gastrointestinal (diagnosis)
• Tuberculosis, Pulmonary (diagnosis)