Abstract | OBJECTIVE:
Wilms' tumor protein (WT1) expression is usually absent in normal glial cells of the CNS but is highly upregulated in brain tumor cells and its expression correlates with tumor grade. However, knowledge on WT1 expression in tumors of the peripheral nerve system (PNS) is limited. As WT1 antibodies not only serve as biomarker for cancerous tissue but also are considered for cancer immunotherapy, knowledge of WT1 expression in tumorous and normal peripheral nerve tissue is important for therapeutical purposes. METHODS: RESULTS: CONCLUSION: WT1 expression in normal and neoplastic tissue differs in the peripheral and the central nervous system. These findings may point to a different functional role of WT1 in the PNS and the CNS.
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Authors | Jens Schittenhelm, John Thiericke, Christoph Nagel, Richard Meyermann, Rudi Beschorner |
Journal | Cancer biomarkers : section A of Disease markers
(Cancer Biomark)
Vol. 7
Issue 2
Pg. 73-7
( 2010)
ISSN: 1875-8592 [Electronic] Netherlands |
PMID | 21178265
(Publication Type: Comparative Study, Journal Article)
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Chemical References |
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Topics |
- Adolescent
- Adult
- Aged
- Case-Control Studies
- Child
- Cranial Nerve Neoplasms
(metabolism, pathology)
- Cranial Nerves
(metabolism)
- Female
- Humans
- Male
- Middle Aged
- Nerve Sheath Neoplasms
(metabolism, pathology)
- Neurilemmoma
(metabolism)
- Neurofibroma
(metabolism)
- Peripheral Nerves
(metabolism)
- WT1 Proteins
(genetics, metabolism)
- Young Adult
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