Three novel NEIL1 promoter polymorphisms in gastric cancer patients.

Abstract

AIM:

To identify genetic polymorphisms in the promoter region of the human base excision repair gene NEIL1 in gastric cancer patients.

METHODS:

The NEIL1 promoter region in DNA from 80 Japanese patients with gastric cancer was searched for genetic polymorphisms by polymerase chain reaction-single-strand conformation polymorphism and subsequent sequencing analyses.

RESULTS:

Three novel genetic polymorphisms, i.e. c.-3769C>T, c.-3170T>G, and c.-2681TA[8], were identified in the NEIL1 promoter region at an allele frequency of 0.6%, 9.4%, and 4.4%, respectively, in Japanese gastric cancer patients.

CONCLUSION:

Three NEIL1 promoter polymorphisms detected in this study may be of importance in gastric carcinogenesis.

• Authors: Masanori Goto, Kazuya Shinmura, Hong Tao, Shoichiro Tsugane, Haruhiko Sugimura
• Journal: World journal of gastrointestinal oncology (World J Gastrointest Oncol) Vol. 2 Issue 2 Pg. 117-20 (Feb 15 2010) ISSN: 1948-5204 [Electronic] China
• PMID: 21160930 (Publication Type: Journal Article)