Significant increase of 8-hydroxydeoxyguanosine in liver DNA of rats following short-term exposure to the peroxisome proliferators di(2-ethylhexyl)phthalate and di(2-ethylhexyl)adipate.

Abstract

8-Hydroxydeoxyguanosine (8-OH-dG) levels were examined in liver and kidney DNA after di(2-ethylhexyl)phthalate (DEHP), di(2-ethylhexyl)adipate (DEHA) and phthalic anhydride administration to male 6-week-old F-344 rats in the diet at concentrations of 1.2, 2.5 and 1.5%, respectively. Significant increases in 8-OH-dG levels were observed only in the liver (target organ of DEHP and DEHA carcinogenesis) DNA after 1 and 2 weeks of treatment with DEHP and DEHA, respectively. The results suggest the involvement of oxidative DNA damage in hepatocarcinogenesis by peroxisome proliferators.

• Authors: A Takagi, K Sai, T Umemura, R Hasegawa, Y Kurokawa
• Journal: Japanese journal of cancer research : Gann (Jpn J Cancer Res) Vol. 81 Issue 3 Pg. 213-5 (Mar 1990) ISSN: 0910-5050 [Print] Japan
• PMID: 2112523 (Publication Type: Journal Article)

Chemical References

• Adipates
• Carcinogens
• Phthalic Acids
• dioctyl adipate
• 8-Hydroxy-2'-Deoxyguanosine
• DNA
• Diethylhexyl Phthalate
• Deoxyguanosine

Topics

• 8-Hydroxy-2'-Deoxyguanosine
• Adipates (administration & dosage, pharmacology)
• Animals
• Carcinogens (pharmacology)
• DNA (metabolism)
• DNA Damage
• Deoxyguanosine (analogs & derivatives, metabolism)
• Diethylhexyl Phthalate (administration & dosage, pharmacology)
• Liver (drug effects, metabolism)
• Liver Neoplasms, Experimental (chemically induced)
• Male
• Microbodies (drug effects, ultrastructure)
• Phthalic Acids (pharmacology)
• Rats
• Rats, Inbred F344