Iron overload in untransfused patients with hemoglobin H disease.

Abstract

Two Chinese patients with hemoglobin (Hb) H disease without a history of blood transfusion developed iron overload at the age of 45 and 53 years, respectively. Human leukocyte antigen (HLA) system types of these 2 patients were A19, A11, B13, B62 and A2, A24, BW55, respectively, which are not related to the common haplotypes for idiopathic hemochromatosis. Since severe iron loading is a rare clinical manifestation in untransfused patients with Hb H disease, the iron overload in both patients may be due to environmental or underlying genetic factors.

• Authors: C K Lin, H W Peng, C H Ho, C H Yung
• Journal: Acta haematologica (Acta Haematol) Vol. 83 Issue 3 Pg. 137-9 ( 1990) ISSN: 0001-5792 [Print] Switzerland
• PMID: 2109453 (Publication Type: Case Reports, Journal Article)

Chemical References

• Iron

Topics

• Humans
• Iron (metabolism)
• Male
• Middle Aged
• Thalassemia (genetics, metabolism)