Abstract |
Alzheimer's disease (AD) is characterized by progressive cognitive impairment and the formation of senile plaques. Silymarin, an extract of milk thistle, has long been used as a medicinal herb for liver diseases. Here we report marked suppression of amyloid β- protein (Aβ) fibril formation and neurotoxicity in PC12 cells after silymarin treatment in vitro. In vivo studies had indicated a significant reduction in brain Aβ deposition and improvement in behavioral abnormalities in amyloid precursor protein (APP) transgenic mice that had been preventively treated with a powdered diet containing 0.1% silymarin for 6 months. The silymarin-treated APP mice also showed less anxiety than the vehicle-treated APP mice. These behavioral changes were associated with a decline in Aβ oligomer production induced by silymarin intake. These results suggest that silymarin is a promising agent for the prevention of AD.
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Authors | Nakaba Murata, Kazuma Murakami, Yusuke Ozawa, Noriaki Kinoshita, Kazuhiro Irie, Takuji Shirasawa, Takahiko Shimizu |
Journal | Bioscience, biotechnology, and biochemistry
(Biosci Biotechnol Biochem)
Vol. 74
Issue 11
Pg. 2299-306
( 2010)
ISSN: 1347-6947 [Electronic] England |
PMID | 21071836
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Protective Agents
- Silymarin
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Topics |
- Alzheimer Disease
(drug therapy, prevention & control)
- Animals
- Disease Models, Animal
- Mental Disorders
(drug therapy)
- Mice
- Mice, Transgenic
- PC12 Cells
- Plaque, Amyloid
(complications, drug therapy)
- Protective Agents
- Rats
- Silymarin
(pharmacology, therapeutic use)
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