Letter to the editor: Panaxadiol's anticancer activity is enhanced by epicatechin.

Abstract

We previously reported the antiproliferative effect of panaxadiol (PD), an active compound in steamed ginseng, on human HCT-116 colorectal cancer cells, and that antioxidants might play a role in this effect. In this study, we observed that PD's antiproliferative effect was significantly enhanced by epicatechin (EC), a strong natural antioxidant in grape seed. Evidence for the synergistic antiproliferative effect was supported by the remarkable increase in the number of apoptotic cells.

• Authors: Miguel Rodriguez, Guang-Jian Du, Chong-Zhi Wang, Chun-Su Yuan
• Journal: The American journal of Chinese medicine (Am J Chin Med) Vol. 38 Issue 6 Pg. 1233-5 ( 2010) ISSN: 1793-6853 [Electronic] Singapore
• PMID: 21061473 (Publication Type: Letter, Research Support, N.I.H., Extramural)

Chemical References

• Antioxidants
• Ginsenosides
• Plant Extracts
• panaxadiol
• Catechin

Topics

• Antineoplastic Combined Chemotherapy Protocols (pharmacology, therapeutic use)
• Antioxidants (pharmacology, therapeutic use)
• Apoptosis (drug effects)
• Camellia sinensis (chemistry)
• Catechin (pharmacology, therapeutic use)
• Cell Line, Tumor
• Cell Proliferation (drug effects)
• Colorectal Neoplasms (drug therapy)
• Dose-Response Relationship, Drug
• Drug Synergism
• Ginsenosides (pharmacology, therapeutic use)
• Humans
• Magnoliopsida (chemistry)
• Panax (chemistry)
• Phytotherapy
• Plant Extracts (pharmacology, therapeutic use)
• Vitis (chemistry)