[Morphological studies of the effects of protein-free diet and branched-chain amino acids (aminosteril-hepa (Frasenius)) on experimental thioacetamide-induced liver damage].

Abstract

The studies were performed in two groups of rats in which experimental hepatic encephalopathy was induced with tioacetamide++. One group of rats on protein-free diet was given intraperitoneally a mixture of amino-acids (Aminosteril-Hepa), the other one was given proteins in the diet in a dose 1 g per kg of body weight. Histological and histochemical studies revealed that free-protein diet with a mixture of aliphatic polybranched amino-acids (Aminosteril-Hepa) inhibited hepatotoxic thioacetamide+ action on the rat liver.

• Authors: H F Nowak, L Zimnoch, P Boroń, R Farbiszewski, T Szpakowska, R Flisiak, B Pytel
• Journal: Patologia polska (Patol Pol) Vol. 41 Issue 1-2 Pg. 90-6 ( 1990) ISSN: 0031-3114 [Print] Poland
• Vernacular Title: Badania morfologiczne nad wpływem diety bezbiałkowej i stosowania aminokwasów wielorozgałezionych (preparat Aminosteril-Hepa firmy Frasenius) na watrobe doświadczalnie uszkodzona tioacetamidem.
• PMID: 2100794 (Publication Type: Comparative Study, English Abstract, Journal Article)

Chemical References

• Amino Acids
• Amino Acids, Branched-Chain
• Dietary Proteins
• aminosteril-hepa
• Thioacetamide

Topics

• Amino Acids (administration & dosage)
• Amino Acids, Branched-Chain (administration & dosage)
• Animals
• Combined Modality Therapy
• Dietary Proteins (administration & dosage)
• Disease Models, Animal
• Hepatic Encephalopathy (chemically induced, diet therapy, pathology)
• Liver (drug effects, pathology)
• Male
• Rats
• Rats, Inbred Strains
• Thioacetamide