A decennial booster dose of reduced antigen content diphtheria, tetanus, acellular pertussis vaccine (Boostrix™) is immunogenic and well tolerated in adults.

Abstract

Reduced-antigen-content diphtheria-tetanus-acellular-pertussis (dTpa) vaccines are predominantly recommended for once-in-a-lifetime use. A second dTpa (Boostrix™, GlaxoSmithKline Biologicals) administration in 164 adults previously vaccinated with dTpa 10 years previously was evaluated. Before the decennial booster, 89.4% and 94.8% subjects were seroprotected (antibodies ≥0.1 IU/mL) for diphtheria and tetanus, respectively. One-month post-booster, all subjects were seroprotected/seropositive against all vaccine antigens. Robust GMC increases indicated a booster response similar to the first booster. The decennial booster was well tolerated without serious adverse events, consistent with product experience. This study supports replacing traditional Td boosters with dTpa, and use of Boostrix™ as a decennial booster. This study is registered at www.clinicaltrials.com NCT00548171.

• Authors: Robert Booy, Olivier Van der Meeren, Su-Peing Ng, Froilan Celzo, Gunasekaran Ramakrishnan, Jeanne-Marie Jacquet
• Journal: Vaccine (Vaccine) Vol. 29 Issue 1 Pg. 45-50 (Dec 10 2010) ISSN: 1873-2518 [Electronic] Netherlands
• PMID: 20974302 (Publication Type: Journal Article)
• Copyright: Copyright © 2010. Published by Elsevier Ltd.

Chemical References

• Boostrix
• Diphtheria-Tetanus-Pertussis Vaccine

Topics

• Adult
• Diphtheria-Tetanus-Pertussis Vaccine (administration & dosage, adverse effects, immunology)
• Female
• Humans
• Immunization, Secondary (adverse effects, methods)
• Male
• Middle Aged