Abstract | PURPOSE: METHODS: RESULTS: Intraocular pressure increased from baseline by ≥ 10 mmHg at ≥ 1 visit through 2 years in 2 eyes (8%) in the laser group, 11 eyes (31%) in the anterior groups, and 6 eyes (17%) in the posterior groups. Among phakic eyes at baseline, 0, 5 (17%), and 1 (3%) in the 3 groups, respectively, underwent cataract surgery before the 2-year visit. CONCLUSION: Based on this small randomized trial, it appears that over 2 years, anterior peribulbar triamcinolone acetonide injections are associated with an increased incidence of IOP elevation and an increased risk of cataract development compared with laser or posterior peribulbar injections. The association of posterior injections with IOP elevation is less certain. Although the study involved eyes with diabetic macular edema, the results should be relevant to other conditions treated with peribulbar corticosteroids.
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Authors | Emily Y Chew, Adam R Glassman, Roy W Beck, Neil M Bressler, Gary E Fish, Fredrick L Ferris, James L Kinyoun, Diabetic Retinopathy Clinical Research Network |
Journal | Retina (Philadelphia, Pa.)
(Retina)
Vol. 31
Issue 2
Pg. 284-9
(Feb 2011)
ISSN: 1539-2864 [Electronic] United States |
PMID | 20948459
(Publication Type: Clinical Trial, Phase II, Comparative Study, Journal Article, Randomized Controlled Trial, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)
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Chemical References |
- Glucocorticoids
- Triamcinolone Acetonide
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Topics |
- Aged
- Cataract
(chemically induced, physiopathology)
- Cataract Extraction
- Combined Modality Therapy
- Diabetic Retinopathy
(drug therapy)
- Disease Progression
- Follow-Up Studies
- Glucocorticoids
(administration & dosage, adverse effects)
- Humans
- Injections
- Intraocular Pressure
(drug effects)
- Laser Coagulation
- Lens, Crystalline
(drug effects)
- Macular Edema
(drug therapy)
- Middle Aged
- Ocular Hypertension
(chemically induced, physiopathology)
- Orbit
- Risk Factors
- Tenon Capsule
- Triamcinolone Acetonide
(administration & dosage, adverse effects)
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