Abstract | OBJECTIVE: METHODS: We compared serum neopterin concentrations, adjusted for age, race, sex, and serum creatinine concentration, in patients with SLE (n=148) or RA (n=166) and control subjects (n=177). In patients with SLE or RA, serum neopterin concentrations were then tested for association (adjusted for age, race, sex, serum creatinine, and medication use) with measures of disease activity or damage, inflammatory markers and mediators, and coronary artery calcium measured by electron beam computed tomography. RESULTS:
Neopterin concentrations were significantly higher in patients with SLE (median 8.0, interquartile range [IQR] 6.5-9.8 nmoles/liter) and RA (median 6.7, IQR 5.3-8.9 nmoles/liter) than controls (median 5.7, IQR 4.8-7.1 nmoles/liter), and were higher in SLE patients than in RA patients (all P<0.001). In SLE, neopterin was significantly correlated with higher erythrocyte sedimentation rate (ESR; P=0.001), tumor necrosis factor α (P<0.001), monocyte chemoattractant protein 1 (P=0.005), and homocysteine concentrations (P=0.01), but in RA, it was only associated with ESR (P=0.01). Neopterin was not associated with coronary calcium in either SLE (P=0.65) or RA (P=0.21). CONCLUSION:
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Authors | Young Hee Rho, Joseph Solus, Paolo Raggi, Annette Oeser, Tebeb Gebretsadik, Ayumi Shintani, C Michael Stein |
Journal | Arthritis care & research
(Arthritis Care Res (Hoboken))
Vol. 63
Issue 4
Pg. 535-41
(Apr 2011)
ISSN: 2151-4658 [Electronic] United States |
PMID | 20890983
(Publication Type: Comparative Study, Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)
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Copyright | Copyright © 2011 by the American College of Rheumatology. |
Chemical References |
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Topics |
- Adult
- Arthritis, Rheumatoid
(complications, immunology, pathology)
- Biomarkers
(blood)
- Cohort Studies
- Coronary Artery Disease
(etiology, immunology, pathology)
- Cross-Sectional Studies
- Female
- Humans
- Lupus Erythematosus, Systemic
(complications, immunology, pathology)
- Macrophage Activation
(physiology)
- Macrophages
(pathology)
- Male
- Middle Aged
- Neopterin
(blood)
- Risk Factors
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