Aminoguanidine reduces oxidative stress and structural lung changes in experimental diabetes mellitus.

Abstract

We evaluated the effect of aminoguanidine on pulmonary oxidative stress and lung structure in an experimental model of diabetes mellitus. Thiobarbituric acid reactive substances (TBARS), histology and arterial blood gases were evaluated in animals with diabetes mellitus (DM group), animals with diabetes mellitus treated with aminoguanidine (DM+AG group), and controls. The TBARS levels were significantly higher in the DM group than in the control and DM+AG groups (2.90 ± 1.12 vs. 1.62 ± 0.28 and 1.68 ± 0.04 nmol/mg protein, respectively), as was PaCO2 when compared with that of the control group (49.2 ± 1.65 vs. 38.12 ± 4.85 mmHg), and PaO2 was significantly higher in the control group (104.5 ± 6.3 vs. 16.30 ± 69.48 and 97.05 ± 14.02 mmHg, respectively). In this experimental model of diabetes mellitus, aminoguanidine reduced oxidative stress, structural tissue alterations, and gas exchange.

• Authors: Fabio Cangeri Di Naso, Luiz Alberto Forgiarini Junior, Luiz Felipe Forgiarini, Marilene Porawski, Alexandre Simões Dias, Norma Anair Possa Marroni
• Journal: Jornal brasileiro de pneumologia : publicacao oficial da Sociedade Brasileira de Pneumologia e Tisilogia (J Bras Pneumol) 2010 Jul-Aug Vol. 36 Issue 4 Pg. 485-9 ISSN: 1806-3756 [Electronic] Brazil
• PMID: 20835596 (Publication Type: Journal Article)

Chemical References

• Guanidines
• Thiobarbituric Acid Reactive Substances

Topics

• Analysis of Variance
• Animals
• Diabetes Mellitus, Experimental (drug therapy, pathology)
• Guanidines (pharmacology)
• Oxidative Stress (drug effects)
• Random Allocation
• Rats
• Rats, Wistar
• Thiobarbituric Acid Reactive Substances (metabolism)