Abstract | BACKGROUND: AIM: METHODS: Four hundred and fifteen patients with clinically diagnosed steroid responsive dermatoses enrolled in this study. They were advised to apply hydrocortisone aceponate (0.127%) lipophilic cream as a thin film to all the affected areas twice daily. Cleansing was done prior to the application with either soap-free cleanser or soap (that would not affect the study result). Use of oral antihistamines and/or antibiotics was permissible. However, other oral/topical steroid use was not permitted during the study. Patients were evaluated at day 0 and at day 21. Data were recorded regarding clinical improvement and side-effects, if any. They were then analyzed to determine the efficacy and safety of the cream. RESULTS: Physician's global evaluation of therapy showed that lesions were cleared in 82 (22.10%), excellent result in 200 (53.91%), good result in 72 (19.41%), fair response in 15 (4.04%) and no change in 2 (0.54%) patients. There was no history of exacerbation in any patient. CONCLUSION: The study showed that hydrocortisone aceponate (0.127%) lipophilic cream is an effective therapeutic agent with a very good safety profile in various steroid responsive dermatoses in the Indian patient population.
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Authors | Amiya Kumar Mukhopadhyay, Vijay Baghel |
Journal | Indian journal of dermatology, venereology and leprology
(Indian J Dermatol Venereol Leprol)
2010 Sep-Oct
Vol. 76
Issue 5
Pg. 591
ISSN: 0973-3922 [Electronic] United States |
PMID | 20827017
(Publication Type: Journal Article, Randomized Controlled Trial)
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Chemical References |
- Emollients
- Immunosuppressive Agents
- hydrocortisone aceponate
- Hydrocortisone
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Topics |
- Administration, Topical
- Adolescent
- Adult
- Aged
- Child
- Child, Preschool
- Emollients
(administration & dosage)
- Female
- Humans
- Hydrocortisone
(administration & dosage, adverse effects, analogs & derivatives)
- Immunosuppressive Agents
(administration & dosage, adverse effects)
- India
- Infant
- Male
- Middle Aged
- Skin Care
(methods)
- Skin Diseases
(drug therapy)
- Treatment Outcome
- Young Adult
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