Abstract | BACKGROUND: METHODS: RESULTS: There was a significant correlation between serum levels of soluble TREM-1 and serum creatinine levels among all patients (r = 0.554, P < 0.0001). The serum-soluble TREM-1/ creatinine ratio was higher in inactive vasculitis patients with infectious complications than in active vasculitis, inactive vasculitis without infection and CKD patients (P = 0.0005, P < 0.0001 and P < 0.0001, respectively), but not significantly different to that in acute pyelonephritis patients. On receiver-operating-characteristic curve analysis, a lower-limit value of 9.40 ng/mg for this ratio had a sensitivity of 84.6% and a specificity of 90.8% in differentiating patients with infection from those without infection. CONCLUSIONS:
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Authors | Kouichi Hirayama, Miho Nagai, Itaru Ebihara, Homare Shimohata, Masaki Kobayashi, Akio Koyama |
Journal | Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association
(Nephrol Dial Transplant)
Vol. 26
Issue 3
Pg. 868-74
(Mar 2011)
ISSN: 1460-2385 [Electronic] England |
PMID | 20709741
(Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Biomarkers
- Membrane Glycoproteins
- Receptors, Immunologic
- TREM1 protein, human
- Triggering Receptor Expressed on Myeloid Cells-1
- Creatinine
- Peroxidase
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Topics |
- Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis
(complications, diagnosis, microbiology)
- Bacterial Infections
(blood, diagnosis, microbiology)
- Biomarkers
(blood)
- Chronic Disease
- Creatinine
(blood)
- Enzyme-Linked Immunosorbent Assay
- Humans
- Kidney Diseases
(blood)
- Kidney Failure, Chronic
- Membrane Glycoproteins
(blood)
- Peroxidase
(immunology)
- ROC Curve
- Receptors, Immunologic
(blood)
- Sensitivity and Specificity
- Triggering Receptor Expressed on Myeloid Cells-1
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