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Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis

Group of systemic vasculitis with a strong association with ANCA. The disorders are characterized by necrotizing inflammation of small and medium size vessels, with little or no immune-complex deposits in vessel walls.
Also Known As:
ANCA Associated Vasculitides; ANCA Associated Vasculitis; ANCA-Associated Vasculitide; Anti Neutrophil Cytoplasmic Antibody Associated Vasculitis; Pauci Immune Vasculitis; Pauci-Immune Vasculitides; Vasculitide, ANCA-Associated; Vasculitides, ANCA-Associated; Vasculitides, Pauci-Immune; Vasculitis, ANCA-Associated; Vasculitis, Pauci-Immune; ANCA-Associated Vasculitides; ANCA-Associated Vasculitis; Pauci-Immune Vasculitis
Networked: 2538 relevant articles (199 outcomes, 320 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1. Vasculitis (Vasculitides)
2. Systemic Lupus Erythematosus (Libman-Sacks Disease)
3. Infections
4. Rheumatoid Arthritis
5. Glomerulonephritis

Experts

1. Specks, Ulrich: 66 articles (05/2022 - 03/2003)
2. Chen, Min: 65 articles (01/2022 - 02/2007)
3. Zhao, Ming-Hui: 65 articles (01/2022 - 10/2005)
4. Merkel, Peter A: 57 articles (05/2022 - 05/2007)
5. Kallenberg, Cees G M: 54 articles (02/2022 - 11/2004)
6. Lee, Sang-Won: 45 articles (10/2022 - 03/2017)
7. Park, Yong-Beom: 45 articles (10/2022 - 03/2017)
8. Song, Jason Jungsik: 44 articles (06/2022 - 03/2017)
9. Ahn, Sung Soo: 39 articles (06/2022 - 03/2017)
10. Stone, John H: 38 articles (10/2022 - 07/2004)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis:
1. Antineutrophil Cytoplasmic Antibodies (ANCA)IBA
04/01/2011 - "A total of 350 samples (8.3%) were positive for ANCA on indirect immunofluorescence (IIF), out of which 212 were guideline recommended and 138 (3.2%) were non-guideline recommended ANCA requests; thus, 3.2% of non-small vessel ANCA associated vasculitis (non-SVAAV) conditions showed false positive results when the population was otherwise unselected. "
01/01/2021 - "Biologics may also be an effective treatment for anti-neutrophil cytoplasmic autoantibody (ANCA)-associated vasculitis, particularly in patients with resistance to standard treatments. "
01/01/2021 - "Advances in the diagnosis and treatment of anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis have led to continued improvement in survival and prognosis over the course of the last 4 decades. "
01/01/2022 - "B cells have been highlighted in the pathogenesis of antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) by the identification of activated B cells in granulomatous lesions and the efficacy of B cell depletion in treatment of AAV patients in the current study; we aimed to investigate the frequency of a specific B cell subset, IgD-CD27hiCD38hi B cells in AAV patients, and its association with the disease severity of AAV. "
01/01/2018 - "A post hoc analysis was conducted using participants enrolled in two randomized, placebo-controlled clinical trials who had active GN due to ANCA-associated vasculitis, had positive ANCA, and achieved remission by month 6. Dipstick and microscopic urinalyses were performed at each visit. "
2. Rituximab (Mabthera)FDA Link
3. Cyclophosphamide (Cytoxan)FDA LinkGeneric
4. Azathioprine (Imuran)FDA LinkGeneric
5. GlucocorticoidsIBA
6. Peroxidase (Myeloperoxidase)IBA
7. avacopanIBA
8. Prednisolone (Predate)FDA LinkGeneric
9. Myeloblastin (Proteinase 3)IBA
10. Prednisone (Sone)FDA LinkGeneric

Therapies and Procedures

1. Therapeutics
2. Remission Induction
3. Plasma Exchange
4. Plasmapheresis
5. Kidney Transplantation