Abstract |
The present study explored the effects of malnutrition and nutritional rehabilitation on the response to glucose in hypothalamic nuclei involved in metabolic homeostasis. Male Wistar rats were malnourished during gestation-lactation (MGL) or at weaning to 55 days (MPW). Two groups of rats were rehabilitated with a balanced diet until 90 days (MGL-R and MPW-R, respectively). After a glucose tolerance test (GTT), brains were processed for Fos immunoreactivity (Fos-IR). Both malnourished groups displayed hyperglycemia after GTT. MGL exhibited an increased number of Fos-IR neurons in the ventromedial hypothalamic nucleus (VMH), while MPW showed increased Fos-IR in the arcuate nucleus ( ARC) and VMH and a decrease in the paraventricular nucleus (PVN), as compared with their controls. Nutritional rehabilitation normalized values of glucose after GTT in both groups, while low number of Fos-IR neurons remained in the ARC, PVN and VMH of MPW-R rats, indicating a deleterious, long-lasting effect after post-weaning malnutrition.
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Authors | María Del Carmen Miñana-Solis, Manuel Angeles-Castellanos, Ruud M Buijs, Carolina Escobar |
Journal | Nutritional neuroscience
(Nutr Neurosci)
Vol. 13
Issue 4
Pg. 152-60
(Aug 2010)
ISSN: 1476-8305 [Electronic] England |
PMID | 20670470
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Blood Glucose
- Proto-Oncogene Proteins c-fos
- Glucose
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Topics |
- Animals
- Arcuate Nucleus of Hypothalamus
(cytology)
- Blood Glucose
(analysis)
- Cell Count
- Diet, Protein-Restricted
- Female
- Glucose
(administration & dosage)
- Glucose Tolerance Test
- Hypothalamus
(cytology, drug effects, metabolism)
- Immunohistochemistry
- Injections, Intraperitoneal
- Male
- Malnutrition
(diet therapy, metabolism, rehabilitation)
- Maternal-Fetal Exchange
- Neurons
(chemistry, cytology)
- Paraventricular Hypothalamic Nucleus
(cytology)
- Pregnancy
- Proto-Oncogene Proteins c-fos
(analysis)
- Rats
- Rats, Wistar
- Ventromedial Hypothalamic Nucleus
(cytology)
- Weaning
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