Elevated antithyroid peroxidase antibodies indicating Hashimoto's thyroiditis are associated with the treatment response in infertile women with polycystic ovary syndrome.

Abstract

In infertile women suffering from polycystic ovary syndrome (PCOS), anti-thyroid peroxidase antibodies values exceeding the upper level of normal were found in significantly more clomiphene citrate resistant patients compared clomiphene citrate responders and metformin responders. Thus, elevated antiTPO levels are associated with poor treatment response in infertile women who suffer from PCOS.

• Authors: Johannes Ott, Stefanie Aust, Christine Kurz, Kazem Nouri, Stefan Wirth, Johannes C Huber, Klaus Mayerhofer
• Journal: Fertility and sterility (Fertil Steril) Vol. 94 Issue 7 Pg. 2895-7 (Dec 2010) ISSN: 1556-5653 [Electronic] United States
• PMID: 20638057 (Publication Type: Evaluation Study, Journal Article)
• Copyright: Copyright © 2010 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved.

Chemical References

• Autoantibodies
• Autoantigens
• Biomarkers, Pharmacological
• Fertility Agents, Female
• Iron-Binding Proteins
• Clomiphene
• TPO protein, human
• Iodide Peroxidase

Topics

• Adult
• Autoantibodies (analysis, blood)
• Autoantigens (immunology)
• Biomarkers, Pharmacological (blood)
• Clomiphene (therapeutic use)
• Drug Resistance (immunology)
• Female
• Fertility Agents, Female (therapeutic use)
• Fertilization in Vitro (methods)
• Hashimoto Disease (blood, complications, diagnosis, immunology)
• Humans
• Infertility, Female (blood, complications, diagnosis, drug therapy)
• Iodide Peroxidase (immunology)
• Iron-Binding Proteins (immunology)
• Ovulation Induction (methods)
• Polycystic Ovary Syndrome (blood, complications, immunology)
• Pregnancy
• Prognosis
• Retrospective Studies
• Young Adult