Elevation of {beta}-amyloid 1-42 autoantibodies in the blood of amnestic patients with mild cognitive impairment.

Abstract

OBJECTIVE:

To develop a blood-based test for screening populations at risk for Alzheimer disease.

DESIGN:

Case-control study. Subjects A total of 180 patients with mild cognitive impairment (MCI) and 105 age-matched, cognitively normal controls.

INTERVENTIONS:

The titer of beta-amyloid 1-42 autoantibodies in the plasma was obtained at the time of diagnosis and evaluated by enzyme-linked immunosorbent assay before and after dissociation of the antigen-antibody complexes. A total of 107 patients with MCI were followed up for 36 months; 70 of the 107 cases progressed to Alzheimer disease.

RESULTS:

The average level of beta-amyloid 1-42 plasma autoantibodies in patients with MCI that progressed to Alzheimer disease, but not that of the stable cases, was significantly higher than in cognitively normal controls (P < .001).

CONCLUSIONS:

The results suggest that the plasma beta-amyloid 1-42 autoantibodies parallel beta-amyloid 42 deposition in the brain, which is known to precede by several years the clinical onset of Alzheimer disease. The evaluation of beta-amyloid 1-42 autoantibodies after dissociation of the complexes is a simple and inexpensive method that can be used to predict the occurrence of Alzheimer disease.

• Authors: Daniela Storace, Sergio Cammarata, Roberta Borghi, Roberta Sanguineti, Luca Giliberto, Alessandra Piccini, Valeria Pollero, Cristina Novello, Carlo Caltagirone, Mark A Smith, Paola Bossù, George Perry, Patrizio Odetti, Massimo Tabaton
• Journal: Archives of neurology (Arch Neurol) Vol. 67 Issue 7 Pg. 867-72 (Jul 2010) ISSN: 1538-3687 [Electronic] United States
• PMID: 20625095 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Amyloid beta-Peptides
• Apolipoprotein E4
• Immunoglobulin G
• Peptide Fragments
• amyloid beta-protein (1-42)

Topics

• Amnesia (blood, complications)
• Amyloid beta-Peptides (immunology)
• Apolipoprotein E4 (genetics)
• Case-Control Studies
• Cognition Disorders (blood, etiology, genetics, immunology)
• Follow-Up Studies
• Humans
• Immunoglobulin G (blood)
• Peptide Fragments (immunology)
• Probability