The prevalence and diagnostic value of perinuclear antineutrophil cytoplasmic antibodies and anti-Saccharomyces cerevisiae antibodies in patients with inflammatory bowel disease in mainland China.

Abstract

BACKGROUND:

Perinuclear anti-neutrophil cytoplasmic (pANCA) and anti-Saccharomyces cerevisiae antibodies (ASCA) have been studied extensively in Western countries. We determined the prevalence of pANCA and ASCA in the mainland Chinese population and the ability of pANCA and ASCA to discriminate between ulcerative colitis (UC) and Crohn's disease (CD).

METHODS:

Two hundred-six unrelated patients with IBD (UC, n=152; CD, n=54), 60 patients with other gastrointestinal diseases, and 80 healthy controls were included. Sera pANCA and ASCA titers were determined by a standardized indirect immunofluorescence technique.

RESULTS:

The sensitivity, specificity, positive and negative predictive values, and positive likelihood ratio of pANCA were calculated for differentiating UC from healthy controls (43.4%, 96.3%, 95.7%, 47.2%, and 11.7, respectively) and ASCA for differentiating CD from healthy controls and (46.3%, 96.3%, 89.3%, 72.6%, and 12.5, respectively). The combination of pANCA and ASCA did not result in greater diagnostic efficiency than either test alone. pANCA was more frequent in UC with extensive or severe phenotype than others. ASCA was associated with severe CD disease activity.

CONCLUSIONS:

pANCA and ASCA are useful in confirming the diagnosis of IBD and differentiating between UC and CD in an IBD cohort in central China.

• Authors: Feng Zhou, Bing Xia, Fubing Wang, Umid Kumar Shrestha, Min Chen, Honglin Wang, Xianyan Shi, Zhitao Chen, Jin Li
• Journal: Clinica chimica acta; international journal of clinical chemistry (Clin Chim Acta) Vol. 411 Issue 19-20 Pg. 1461-5 (Oct 09 2010) ISSN: 1873-3492 [Electronic] Netherlands
• PMID: 20570669 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright 2010 Elsevier B.V. All rights reserved.

Chemical References

• Antibodies, Antineutrophil Cytoplasmic
• Antibodies, Fungal

Topics

• Antibodies, Antineutrophil Cytoplasmic (blood)
• Antibodies, Fungal (blood)
• Case-Control Studies
• China (epidemiology)
• Colitis, Ulcerative (diagnosis)
• Crohn Disease (diagnosis)
• Diagnosis, Differential
• Humans
• Inflammatory Bowel Diseases (diagnosis, epidemiology)
• Prevalence
• Saccharomyces cerevisiae (immunology)