A clinical trial of pulpotomy vs. root canal therapy of mature molars.

Abstract	Root canal therapy (RCT) and tooth extraction are the main treatment options for irreversible pulpitis or its sequelae. Pulpotomy is an alternative treatment; however, more evidence is required. If outcomes of pulpotomy with a calcium-enriched mixture (PCEM) are non-inferior for mature molars with irreversible pulpitis compared with those from one-visit RCT (ORCT), this may be a beneficial treatment option. Four hundred seven individuals met the inclusion criteria and were randomly allocated [PCEM (n = 205), ORCT (n = 202)]. We used NRS questionnaires to record pain intensity. Six-month clinical and radiographic successes were assessed. Individuals in the ORCT arm reported significantly more post-operative pain than those in the PCEM arm (P < 0.001). Clinical success rates in the two arms showed no statistically significant difference; however, the radiographic success rates were significantly greater in the PCEM arm (P < 0.001). This trial suggests PCEM as an alternative for treatment of irreversible pulpitis. If long-term results confirm initial ones, PCEM may revolutionize oral health worldwide.
Authors	S Asgary, M J Eghbal
Journal	Journal of dental research (J Dent Res) Vol. 89 Issue 10 Pg. 1080-5 (Oct 2010) ISSN: 1544-0591 [Electronic] United States
PMID	20562409 (Publication Type: Comparative Study, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't, Retracted Publication)
Chemical References	Analgesics CaO-MgO-SiO2 glass Calcium Compounds Dental Cements Epoxy Resins Polyvinyls Root Canal Filling Materials calcium oxide-diphosphorus pentoxide-silicon dioxide-aluminum oxide glass epoxy resin-based root canal sealer Cavit Gutta-Percha Zinc Oxide Calcium Sulfate
Topics	Adolescent Adult Aged Analgesics (therapeutic use) Calcium Compounds (therapeutic use) Calcium Sulfate (therapeutic use) Child Dental Cements (therapeutic use) Epoxy Resins (therapeutic use) Female Follow-Up Studies Glass Gutta-Percha (therapeutic use) Humans Male Middle Aged Molar (pathology) Pain (drug therapy) Pain Measurement Polyvinyls (therapeutic use) Pulpitis (therapy) Pulpotomy (methods) Root Canal Filling Materials (therapeutic use) Root Canal Preparation (methods) Root Canal Therapy (methods) Treatment Outcome Young Adult Zinc Oxide (therapeutic use)

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